Celsr1 MGI Mouse Gene Detail - MGI:1100883 - cadherin, EGF LAG seven-pass G-type receptor 1

Symbol

Celsr1
Name

cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms

Adgrc1, crash, Crsh, Scy

Feature Type

protein coding gene
IDs

MGI:1100883
NCBI Gene: 12614
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:85783130-85918404 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.42 cM
Mapping Data

2 experiments

SNPs within 2kb

4813 from dbSNP Build 142
Strain Annotations

19
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100883	protein coding gene	Chr15:85782959-85918424 (-)
129S1/SvImJ	ENSMUSG00200035309	protein coding gene	Chr15:82910281-83046533 (-)
A/J	ENSMUSG00195019162	protein coding gene	Chr15:82836622-82973398 (-)
AKR/J	ENSMUSG00220028479	protein coding gene	Chr15:82889834-83026629 (-)
BALB/cJ	ENSMUSG00180014831	protein coding gene	Chr15:82713510-82849762 (-)
C3H/HeJ	ENSMUSG00175027369	protein coding gene	Chr15:83024196-83160963 (-)
C57BL/6NJ	ENSMUSG00215018055	protein coding gene	Chr15:82802655-82937930 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020135	protein coding gene	Chr15:79888030-80025498 (-)
CAST/EiJ	ENSTCUG00005029689	protein coding gene	Chr15:82304697-82441161 (-)
CBA/J	ENSMUSG00210013037	protein coding gene	Chr15:82799086-82935867 (-)
DBA/2J	ENSMUSG00185021771	protein coding gene	Chr15:82825451-82961924 (-)
FVB/NJ	ENSMUSG00205032375	protein coding gene	Chr15:82585237-82722046 (-)
JF1/MsJ	ENSUMUG00000027118	protein coding gene	Chr15:82342071-82478428 (-)
LP/J	ENSMUSG00230043873	protein coding gene	Chr15:86150441-86286671 (-)
NOD/ShiLtJ	ENSMUSG00190022337	protein coding gene	Chr15:82822556-82959315 (-)
NZO/HlLtJ	ENSMUSG00225049888	protein coding gene	Chr15:86488733-86624843 (-)
PWK/PhJ	ENSLUMG00010030470	protein coding gene	Chr15:82548696-82685341 (-)
SPRET/EiJ	ENSMSPG00010012041	protein coding gene	Chr15:84207859-84344200 (-)
WSB/EiJ	ENSIUOG00005010901	protein coding gene	Chr15:82889391-83026805 (-)

Human Ortholog

CELSR1, cadherin EGF LAG seven-pass G-type receptor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CELSR1, cadherin EGF LAG seven-pass G-type receptor 1
Synonyms

ADGRC1, CDHF9, FMI2, HFMI2, LMPHM9, ME2, YNS
Links

HGNC:1850

NCBI Gene ID: 9620

UniProt: Q9NYQ6
Chr Location

22q13.31; chr22:46360834-46537620 (-) GRCh38

MGI Vertebrate Homology

Celsr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CELSR1
Gene Tree

Celsr1

Diseases

2 with human CELSR1 associations

				Human Disease	Mouse Models
				hereditary lymphedema IDs hereditary lymphedema DOID:0050580 ICD9CM:757.0 OMIM:PS153100 ORDO:79452 UMLS_CUI:C1313885
				yellow nail syndrome IDs yellow nail syndrome DOID:0050468 ICD10CM:L60.5 MESH:D056684 NCI:C85238 OMIM:153300 UMLS_CUI:C0221348

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

less

Phenotype Summary

62 phenotypes from 8 alleles in 12 genetic backgrounds
11 phenotypes from multigenic genotypes
65 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

8
Radiation induced

2
Spontaneous

2
Targeted

7
Genomic Mutations

3 involving Celsr1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

145 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice exhibit kinky tails, variable neural tube defects, abnormal hair follicle orientation, whorl-like hair patterns, and partial prenatal lethality. ENU-induced mutants show defects in planar polarity of inner ear hair cells and complete perinatal lethality due to craniorachischisis.

less

All GO Annotations

54
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

86
cDNA Data

56
Literature Summary

66

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase celsr1

ZFIN celsr1a, celsr1b

less

All Sequences

58
RefSeq

14
UniProt

6
CCDS

CCDS37172.1

Ensembl

ENSMUSG00000016028 (Evidence)
NCBI Gene

12614

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016028	Ensembl Gene Model \| MGI Sequence Detail	135275	C57BL/6J	± kb
transcript	ENSMUST00000016172	Ensembl \| MGI Sequence Detail	11305	Not Applicable
polypeptide	ENSMUSP00000016172	Ensembl \| MGI Sequence Detail	3034	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000005318 cadherin EGF LAG seven-pass G-type receptor 1

(term hierarchy)
PDB

8VY2
InterPro Domains

IPR032471 AGRL2-4 , GAIN subdomain A

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR056286 CELSR1-3-like, ninth cadherin domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR046338 GAIN domain superfamily

IPR057244 GAIN, subdomain B

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR000203 GPS motif

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR001791 Laminin G domain

IPR002049 Laminin-type EGF domain
GlyGen

O35161 30 sites, 3 N-linked glycans (5 sites), 1 O-linked glycan (5 sites)

less

All nucleic 68

Genomic 2

cDNA 57

Primer pair 5

Other 4

Antibodies 7

Microarray probesets 3

less

MGI:1861995, MGI:2387968

Summaries

All 146

Developmental Gene Expression 66

Diseases 2

Gene Ontology 18

Phenotypes 65
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:388312 Sharan R, et al., Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis. Curr Biol. 2026 Jun 23;

TSS for Celsr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135778	Chr15:85918378-85918409 (-)	10 bp
Tssr135777	Chr15:85918244-85918307 (-)	128 bp
Tssr135776	Chr15:85918217-85918228 (-)	181 bp
Tssr135775	Chr15:85914162-85914195 (-)	4,225 bp
Tssr135774	Chr15:85905668-85905681 (-)	12,729 bp
Tssr135773	Chr15:85903998-85904002 (-)	14,404 bp
Tssr135772	Chr15:85889186-85889190 (-)	29,216 bp
Tssr135771	Chr15:85847718-85847724 (-)	70,683 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24