Gene Expression Literature Summary

• Symbol: Celsr1
• Name: cadherin, EGF LAG seven-pass G-type receptor 1
• ID: MGI:1100883

58 matching records from 58 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E5.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)						2			2	1	3		2		2	2	2	1	6		2				2	1	2		3
In situ RNA (section)			1		2	1			1	2	2	1	5	1	3		4	1	4	1	3		2				2		3
Immunohistochemistry (whole mount)	1						2		1						1		1		2		8	1		1	1		1	3	3
In situ RNA (whole mount)		1	1	1	4	2	2	1	3	1	3		1	1					1									2	1
Western blot							2		1																				2
RT-PCR						1		1					1		1		1		3		1				1		1	2	1
cDNA clones			1		1		2		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Celsr1  cadherin, EGF LAG seven-pass G-type receptor 1   (Synonyms: Adgrc1, crash, Crsh, Scy)
Results	Reference
3	J:310852 Basta LP, Hill-Oliva M, Paramore SV, Sharan R, Goh A, Biswas A, Cortez M, Little KA, Posfai E, Devenport D, New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo. Development. 2021 Sep 15;148(18):dev199695
2*	J:333055 Basta LP, Sil P, Jones RA, Little KA, Hayward-Lara G, Devenport D, Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity. Front Cell Dev Biol. 2022;10:1064907
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:323868 Bellchambers HM, Ware SM, Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects. Hum Mol Genet. 2021 Nov 30;30(24):2402-2415
1	J:239251 Brzoska HL, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA, Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016 Dec;90(6):1274-1284
1*	J:162624 Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM, Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell. 2010 Jul 20;19(1):138-47
3*	J:247897 Cetera M, Leybova L, Woo FW, Deans M, Devenport D, Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns. Dev Biol. 2017 Aug 01;428(1):188-203
1	J:340722 Cetera M, Sharan R, Hayward-Lara G, Phillips B, Biswas A, Halley M, Beall E, vonHoldt B, Devenport D, Region-specific reversal of epidermal planar polarity in the rosette fancy mouse. Development. 2023 Sep 1;150(17)
3	J:269131 Cortijo C, Gouzi M, Tissir F, Grapin-Botton A, Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep. 2012 Dec 27;2(6):1593-606
6*	J:125765 Crompton LA, Du Roure C, Rodriguez TA, Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues. Dev Dyn. 2007 Nov;236(11):3137-43
3	J:84285 Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, Nolan PM, Steel KP, Brown SD, Gray IC, Murdoch JN, Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol. 2003 Jul 1;13(13):1129-33
5	J:145627 Devenport D, Fuchs E, Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol. 2008 Nov;10(11):1257-68
4	J:174422 Devenport D, Oristian D, Heller E, Fuchs E, Mitotic internalization of planar cell polarity proteins preserves tissue polarity. Nat Cell Biol. 2011;13(8):893-902
3	J:240403 Duncan JS, Stoller ML, Francl AF, Tissir F, Devenport D, Deans MR, Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development. Dev Biol. 2017 Mar 15;423(2):126-137
1*	J:293794 Durbin MD, O'Kane J, Lorentz S, Firulli AB, Ware SM, SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects. Dev Biol. 2020 Aug 15;464(2):124-136
1	J:242825 Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S, A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 May 01;9(5):585-96
5*	J:72602 Formstone CJ, Little PF, The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development. Mech Dev. 2001 Nov;109(1):91-4
10	J:164131 Formstone CJ, Moxon C, Murdoch J, Little P, Mason I, Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Mol Cell Neurosci. 2010 Jul;44(3):210-22
1	J:139139 Garcia-Garcia MJ, Shibata M, Anderson KV, Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008 Sep;135(18):3053-62
1	J:280404 Ghimire SR, Deans MR, Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons. J Neurosci. 2019 Oct 9;39(41):8013-8023
2	J:264107 Ghimire SR, Ratzan EM, Deans MR, A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea. Development. 2018 Jun 14;145(12):dev159012
1	J:235628 Glasco DM, Pike W, Qu Y, Reustle L, Misra K, Di Bonito M, Studer M, Fritzsch B, Goffinet AM, Tissir F, Chandrasekhar A, The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. Dev Biol. 2016 Sep 1;417(1):40-9
16*	J:51705 Hadjantonakis AK, Formstone CJ, Little PFR, mCelsr1 is an evolutionarily conserved seven-pass transmembrane receptor and is expressed during mouse embryonic development. Mech Dev. 1998 Nov;78(1-2):91-5
4	J:43499 Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM , Little PF, Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics. 1997 Oct 1;45(1):97-104
1	J:243870 He H, Huang M, Sun S, Wu Y, Lin X, Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development. PLoS Genet. 2017 Aug;13(8):e1006992
4*	J:331972 Hummel D, Becks A, Men H, Bryda EC, Glasco DM, Chandrasekhar A, Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent incorrect rostral migration of facial branchiomotor neurons. Development. 2022 Nov 15;149(22):dev200553
1	J:213915 Kadzik RS, Cohen ED, Morley MP, Stewart KM, Lu MM, Morrisey EE, Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12444-9
1	J:324183 Kimura-Yoshida C, Mochida K, Kanno SI, Matsuo I, USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components. Commun Biol. 2022 Apr 19;5(1):378
3	J:267222 Kimura-Yoshida C, Mochida K, Nakaya MA, Mizutani T, Matsuo I, Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis. Nat Commun. 2018 Oct 3;9(1):4059
1	J:275100 Lindenmaier LB, Parmentier N, Guo C, Tissir F, Wright KM, Dystroglycan is a scaffold for extracellular axon guidance decisions. Elife. 2019 Feb 13;8:e42143
1*	J:233664 Luxenburg C, Heller E, Pasolli HA, Chai S, Nikolova M, Stokes N, Fuchs E, Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity. Nat Cell Biol. 2015 May;17(5):592-604
1	J:194042 Mahaffey JP, Grego-Bessa J, Liem KF Jr, Anderson KV, Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
1	J:261809 Mayer C, Hafemeister C, Bandler RC, Machold R, Batista Brito R, Jaglin X, Allaway K, Butler A, Fishell G, Satija R, Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
1	J:240026 Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP, Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP, Shimono A, Shiratori H, Hamada H, A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017 Mar 13;40(5):439-452.e4
1	J:216413 Murdoch JN, Damrau C, Paudyal A, Bogani D, Wells S, Greene ND, Stanier P, Copp AJ, Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice. Dis Model Mech. 2014 Oct;7(10):1153-63
1	J:297063 Najarro EH, Huang J, Jacobo A, Quiruz LA, Grillet N, Cheng AG, Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea. Development. 2020 Oct 5;147(19):dev191981
2*	J:281425 Nakaniwa M, Kawasaki M, Kawasaki K, Yamada A, Meguro F, Takeyasu M, Ohazama A, Primary cilia in murine palatal rugae development. Gene Expr Patterns. 2019 Jun 19;34:119062
1	J:330740 Narayanan R, Pham L, Kerimoglu C, Watanabe T, Castro Hernandez R, Sokpor G, Ulmke PA, Kiszka KA, Tonchev AB, Rosenbusch J, Seong RH, Teichmann U, Frahm J, Fischer A, Bonn S, Stoykova A, Staiger JF, Tuoc T, Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. iScience. 2018 Jun 29;4:109-126
4	J:250242 Panousopoulou E, Hobbs C, Mason I, Green JB, Formstone CJ, Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body. J Cell Sci. 2016 May 01;129(9):1915-27
2*	J:163834 Paudyal A, Damrau C, Patterson VL, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris DP, Dean CH, Henderson DJ, Murdoch JN, The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol. 2010;10:87
2	J:269234 Pujol F, Hodgson T, Martinez-Corral I, Prats AC, Devenport D, Takeichi M, Genot E, Makinen T, Francis-West P, Garmy-Susini B, Tatin F, Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1732-1735
5	J:162560 Qu Y, Glasco DM, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN, Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F, Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci. 2010 Jul 14;30(28):9392-401
1*	J:202995 Ren DD, Kelly M, Kim SM, Grimsley-Myers CM, Chi FL, Chen P, Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice. Dev Dyn. 2013 Dec;242(12):1454-65
1	J:298302 Ru J, Guo D, Fan J, Zhang J, Ju R, Ouyang H, Wei L, Liu Y, Liu C, Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis. Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):6
6	J:75307 Shima Y, Copeland NG, Gilbert DJ, Jenkins NA, Chisaka O, Takeichi M, Uemura T, Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development. Dev Dyn. 2002 Mar;223(3):321-32
3	J:314818 Stahley SN, Basta LP, Sharan R, Devenport D, Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes. Elife. 2021 Feb 2;10:e62097
1	J:261565 Stoller ML, Roman O Jr., Deans MR, Domineering non-autonomy in Vangl1;Vangl2 double mutants demonstrates intercellular PCP signaling in the vertebrate inner ear. Dev Biol. 2018 May 1;437(1):17-26
3	J:277380 Telley L, Agirman G, Prados J, Amberg N, Fievre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D, Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 2019 May 10;364(6440)
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
4*	J:75697 Tissir F, De-Backer O, Goffinet AM, Lambert de Rouvroit C, Developmental expression profiles of Celsr (Flamingo) genes in the mouse. Mech Dev. 2002 Mar;112(1-2):157-60
1*	J:310323 Vied CM, Freudenberg F, Wang Y, Raposo AA, Feng D, Nowakowski RS, A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development. Front Neurosci. 2014;8:257
1	J:237534 Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M, Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development. 2016 Dec 01;143(23):4441-4451
2	J:335806 Yan L, Yin H, Mi Y, Wu Y, Zheng Y, Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Front Cell Dev Biol. 2023;11:1084245
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1	J:192804 Yates LL, Schnatwinkel C, Hazelwood L, Chessum L, Paudyal A, Hilton H, Romero MR, Wilde J, Bogani D, Sanderson J, Formstone C, Murdoch JN, Niswander LA, Greenfield A, Dean CH, Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol. 2013 Jan 15;373(2):267-80
3	J:159690 Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH, The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet. 2010 Jun 1;19(11):2251-67
1	J:266389 Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR, The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018 Jul 19;9(1):2815
1	J:206311 Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ, beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014 Jan;141(1):148-57