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Krt6a Gene Detail
Summary
  • Symbol
    Krt6a
  • Name
    keratin 6A
  • Synonyms
    Krt2-6a, Krt2-6c, mK6[a], MK6a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100845
    NCBI Gene: 16687
  • Member of
    Krt6 cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101598363-101602746 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.97 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100845
 protein coding gene Chr15:101598345-101602746 (-)
129S1/SvImJ ENSMUSG00200051603
 protein coding gene Chr15:98817126-98821521 (-)
A/J ENSMUSG00195043236
 protein coding gene Chr15:98693559-98697959 (-)
AKR/J ENSMUSG00220047726
 protein coding gene Chr15:98683691-98688088 (-)
BALB/cJ ENSMUSG00180037571
 protein coding gene Chr15:98587122-98591517 (-)
C3H/HeJ ENSMUSG00175034764
 protein coding gene Chr15:98873551-98877950 (-)
C57BL/6NJ ENSMUSG00215048418
 protein coding gene Chr15:98639191-98643588 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005045490
 protein coding gene Chr15:98114722-98119114 (-)
CBA/J ENSMUSG00210031448
 protein coding gene Chr15:98646723-98651121 (-)
DBA/2J ENSMUSG00185040072
 protein coding gene Chr15:98683670-98688067 (-)
FVB/NJ ENSMUSG00205030914
 protein coding gene Chr15:98388153-98392550 (-)
JF1/MsJ ENSUMUG00000049807
 protein coding gene Chr15:98142871-98147267 (-)
LP/J ENSMUSG00230036189
 protein coding gene Chr15:102040759-102045154 (-)
NOD/ShiLtJ ENSMUSG00190048397
 protein coding gene Chr15:98622961-98627358 (-)
NZO/HlLtJ ENSMUSG00225028006
 protein coding gene Chr15:102224850-102229246 (-)
PWK/PhJ ENSLUMG00010042930
 protein coding gene Chr15:98355625-98360018 (-)
SPRET/EiJ ENSMSPG00010037197
 protein coding gene Chr15:100150966-100155345 (-)
WSB/EiJ ENSIUOG00005033359
 protein coding gene Chr15:98775795-98780190 (-)



Homology
more
  • Human Ortholog
    KRT6A, keratin 6A
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT6A, keratin 6A
  • Synonyms
    CK6A, CK-6C, CK6C, CK6D, CK-6E, K6A, K6C, K6D, KRT6C, KRT6D, PC3
  • Links
    NCBI Gene ID: 3853
    UniProt: P02538

  • Chr Location
    12q13.13; chr12:52487176-52493257 (-)  GRCh38
  • Human Ortholog
    KRT6B, keratin 6B
  • Synonyms
    CK-6B, CK6B, K6B, KRTL1, PC2, PC4
  • Links
    NCBI Gene ID: 3854
    UniProt: P04259

  • Chr Location
    12q13.13; chr12:52446651-52452146 (-)  GRCh38
  • Human Ortholog
    KRT6C, keratin 6C
  • Synonyms
    K6E, KRT6E, PPKNEFD
  • Links
    NCBI Gene ID: 286887
    UniProt: P48668

  • Chr Location
    12q13.13; chr12:52468516-52473805 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KRT6A,KRT6B,KRT6C associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 6 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    3 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit delayed wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    99
  • cDNA Data
    35
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16687 NCBI Gene Model | MGI Sequence Detail 4384 C57BL/6J ±  kb
    transcript NM_008476 RefSeq | MGI Sequence Detail 2264 C57BL/6  
    polypeptide P50446 UniProt | EBI | MGI Sequence Detail 553 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR003054 Keratin, type II
      IPR032444 Keratin type II head
    • GlyGen
      P50446 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 9
      cDNA 35
      Primer pair 9
      Other 2
      Antibodies 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1333767, MGI:1913622
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 30
      Diseases 2
      Gene Ontology 9
      Phenotypes 49
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:388928 Adelizzi E, et al., Ectodermal loss of ARHGAP29 alters epithelial morphology and disrupts murine palatogenesis. Development. 2026 Jun 15;153(12):dev205636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory