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Kpna6 Gene Detail
Summary
  • Symbol
    Kpna6
  • Name
    karyopherin subunit alpha 6
  • Synonyms
    importin alpha 7, IPOA7, NPI-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100836
    NCBI Gene: 16650
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129537773-129566560 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.28 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100836
protein coding gene Chr4:129537772-129566560 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028836
protein coding gene Chr4:131581318-131614970 (-)
A/J MGP_AJ_G0028795
protein coding gene Chr4:126320870-126352449 (-)
AKR/J MGP_AKRJ_G0028748
protein coding gene Chr4:129844004-129877351 (-)
BALB/cJ MGP_BALBcJ_G0028818
protein coding gene Chr4:126928396-126959522 (-)
C3H/HeJ MGP_C3HHeJ_G0028532
protein coding gene Chr4:129897535-129938677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029260
protein coding gene Chr4:136527588-136558081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026532
protein coding gene Chr4:119451792-119483512 (-)
CAST/EiJ MGP_CASTEiJ_G0027964
protein coding gene Chr4:128086806-128119067 (-)
CBA/J MGP_CBAJ_G0028498
protein coding gene Chr4:139945129-139977036 (-)
DBA/2J MGP_DBA2J_G0028647
protein coding gene Chr4:126757055-126788771 (-)
FVB/NJ MGP_FVBNJ_G0028614
protein coding gene Chr4:125513519-125545335 (-)
LP/J MGP_LPJ_G0028748
protein coding gene Chr4:131888637-131919817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028640
protein coding gene Chr4:144727345-144759295 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029298
protein coding gene Chr4:130213414-130244629 (-)
PWK/PhJ MGP_PWKPhJ_G0027686
protein coding gene Chr4:123359410-123388961 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027512
protein coding gene Chr4:126081122-126115126 (-)
WSB/EiJ MGP_WSBEiJ_G0028045
protein coding gene Chr4:130341637-130373481 (-)



Homology
more
  • Human Ortholog
    KPNA6, karyopherin subunit alpha 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPNA6, karyopherin subunit alpha 6
  • Synonyms
    IPOA7
  • Links
    NCBI Gene ID: 23633
    neXtProt AC: NX_O60684
    UniProt: O60684

  • Chr Location
    1p35.2; chr1:32108056-32176563 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 7 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a null mutation are infertile and show a block in zygotic genome activation. In male mice, homozygous deficiency results in multiple defects in both germ cells and Sertoli cells culminating in oligozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003731 Ensembl Gene Model | MGI Sequence Detail 28788 C57BL/6J ±  kb
    transcript ENSMUST00000102590 Ensembl | MGI Sequence Detail 5710 Not Applicable  
    polypeptide ENSMUSP00000099650 Ensembl | MGI Sequence Detail 536 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      cDNA 153
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:43573 Tsuji L, et al., Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett. 1997 Oct 13;416(1):30-4
    • Latest
      J:311959 Liu N, et al., Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis. Development. 2021 Oct 1;148(19):dev198374

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/24/2024
    MGI 6.24
    The Jackson Laboratory