About   Help   FAQ
Tmem38b Gene Detail
Summary
  • Symbol
    Tmem38b
  • Name
    transmembrane protein 38B
  • Synonyms
    1600017F22Rik, D4Ertd89e, TRIC-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098718
    NCBI Gene: 52076
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:53826045-53862019 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 28.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1176 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098718
protein coding gene Chr4:53825988-53862019 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028303
protein coding gene Chr4:52480294-52524031 (+)
A/J MGP_AJ_G0028264
protein coding gene Chr4:50457470-50496817 (+)
AKR/J MGP_AKRJ_G0028213
protein coding gene Chr4:51842577-51887595 (+)
BALB/cJ MGP_BALBcJ_G0028283
protein coding gene Chr4:50645325-50682660 (+)
C3H/HeJ MGP_C3HHeJ_G0028004
protein coding gene Chr4:52380408-52421205 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028724
protein coding gene Chr4:54402847-54444899 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026032
protein coding gene Chr4:47404436-47440639 (+)
CAST/EiJ MGP_CASTEiJ_G0027442
protein coding gene Chr4:52028370-52068704 (+)
CBA/J MGP_CBAJ_G0027969
protein coding gene Chr4:56254593-56302403 (+)
DBA/2J MGP_DBA2J_G0028119
protein coding gene Chr4:50432860-50472877 (+)
FVB/NJ MGP_FVBNJ_G0028086
protein coding gene Chr4:49653994-49696178 (+)
LP/J MGP_LPJ_G0028218
protein coding gene Chr4:52585507-52625103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028110
protein coding gene Chr4:59456439-59501965 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028760
protein coding gene Chr4:52064921-52107510 (+)
PWK/PhJ MGP_PWKPhJ_G0027167
protein coding gene Chr4:50372486-50411967 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026995
protein coding gene Chr4:51348174-51389636 (+)
WSB/EiJ MGP_WSBEiJ_G0027520
protein coding gene Chr4:51971349-52012500 (+)



Homology
more
  • Human Ortholog
    TMEM38B, transmembrane protein 38B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM38B, transmembrane protein 38B
  • Synonyms
    bA219P18.1, C9orf87, D4Ertd89e, OI14, TRIC-B, TRICB
  • Links
    NCBI Gene ID: 55151
    neXtProt AC: NX_Q9NVV0
    UniProt: Q9NVV0

  • Chr Location
    9q31.2; chr9:105694541-105776629 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TMEM38B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null newborn mice die of respiratory failure showing atelectasis, pulmonary congestion, impaired maturation of alveolar type II cells, reduced lamellar body formation, abnormal synthesis and secretion of surfactant phospholipids, and impaired Ca2+ release in alveolar type II cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028420 Ensembl Gene Model | MGI Sequence Detail 35975 C57BL/6J ±  kb
    transcript ENSMUST00000030127 Ensembl | MGI Sequence Detail 2862 Not Applicable  
    polypeptide ENSMUSP00000030127 Ensembl | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919255, MGI:3034371, MGI:3034649
    References
    more
    • Summaries
      All 44
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:343609 Ichimura A, et al., Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice. Cell Death Dis. 2023 Dec 20;14(12):848

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory