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Nrxn2 Gene Detail
Summary
  • Symbol
    Nrxn2
  • Name
    neurexin II
  • Synonyms
    6430591O13Rik, mKIAA0921, neurexin II alpha, neurexin II beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096362
    NCBI Gene: 18190
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6468786-6583247 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096362
 protein coding gene Chr19:6468761-6594199 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024764
 protein coding gene Chr19:3475480-3613249 (+)
A/J MGP_AJ_G0024730
 protein coding gene Chr19:3285382-3411334 (+)
AKR/J MGP_AKRJ_G0024703
 protein coding gene Chr19:3382739-3511657 (+)
BALB/cJ MGP_BALBcJ_G0024730
 protein coding gene Chr19:3282682-3410289 (+)
C3H/HeJ MGP_C3HHeJ_G0024498
 protein coding gene Chr19:3403250-3532862 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025176
 protein coding gene Chr19:3525368-3671457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022610
 protein coding gene Chr19:3208356-3338550 (+)
CAST/EiJ MGP_CASTEiJ_G0023970
 protein coding gene Chr19:3428770-3555090 (+)
CBA/J MGP_CBAJ_G0024470
 protein coding gene Chr19:3696888-3855960 (+)
DBA/2J MGP_DBA2J_G0024597
 protein coding gene Chr19:3272933-3398114 (+)
FVB/NJ MGP_FVBNJ_G0024563
 protein coding gene Chr19:3289624-3416991 (+)
LP/J MGP_LPJ_G0024683
 protein coding gene Chr19:3438516-3572363 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024592
 protein coding gene Chr19:3520413-3656860 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025224
 protein coding gene Chr19:3407866-3537527 (+)
PWK/PhJ MGP_PWKPhJ_G0023716
 protein coding gene Chr19:3307520-3436346 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023521
 protein coding gene Chr19:3367029-3493361 (+)
WSB/EiJ MGP_WSBEiJ_G0024032
 protein coding gene Chr19:3423913-3553847 (+)



Homology
more
  • Human Ortholog
    NRXN2, neurexin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
Human Diseases
more
  • Diseases
    1 with Nrxn2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 5 alleles in 5 genetic backgrounds
    16 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are generally non-viable; surviving homozygotes show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    41
  • cDNA Data
    16
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18190 NCBI Gene Model | MGI Sequence Detail 114462 C57BL/6J ±  kb
    transcript NM_001369363 RefSeq | MGI Sequence Detail 6663 C57BL/6  
    polypeptide E9Q7X7 UniProt | EBI | MGI Sequence Detail 1710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000742 EGF-like domain
      IPR001791 Laminin G domain
      IPR003585 Neurexin/syndecan/glycophorin C
      IPR027789 Syndecan/Neurexin domain
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 17
      Primer pair 2
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2444066
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
    • Latest
      J:346918 Chofflet N, et al., Structural and functional characterization of the IgSF21-neurexin2alpha complex and its related signaling pathways in the regulation of inhibitory synapse organization. Front Mol Neurosci. 2024;17:1371145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory