Sequence Detail

ID/Version

E9Q7X7 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Neurexin-2 {ECO:0000305};AltName: Full=Neurexin II-alpha;AltName: Full=Neurexin-2-alpha {ECO:0000303|PubMed:28864826};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1710 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nrxn2	neurexin II	39	107	4	25

Sequence references in MGI

J:177327 Matsuda K, et al., Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur J Neurosci. 2011 Apr;33(8):1447-61
J:184952 Wei P, et al., The Cbln family of proteins interact with multiple signaling pathways. J Neurochem. 2012 Jun;121(5):717-29
J:201987 Pettem KL, et al., The Specific alpha-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development. Neuron. 2013 Oct 2;80(1):113-28
J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109
J:249826 Tanabe Y, et al., IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2alpha. Nat Commun. 2017 Sep 01;8(1):408
J:277096 Zhang P, et al., Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018 Sep 6;174(6):1450-1464.e23
J:291190 Kim H, et al., Calsyntenin-3 interacts with both alpha- and beta-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways. J Biol Chem. 2020 Jul 3;295(27):9244-9262
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89