About   Help   FAQ
Vegfc Gene Detail
Summary
  • Symbol
    Vegfc
  • Name
    vascular endothelial growth factor C
  • Synonyms
    VEGF-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:109124
    NCBI Gene: 22341
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:54530567-54639489 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 29.20 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    900 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109124
 protein coding gene Chr8:54530567-54640131 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033610
 protein coding gene Chr8:53717330-53829276 (+)
A/J MGP_AJ_G0033592
 protein coding gene Chr8:51477160-51576261 (+)
AKR/J MGP_AKRJ_G0033517
 protein coding gene Chr8:52930543-53041217 (+)
BALB/cJ MGP_BALBcJ_G0033589
 protein coding gene Chr8:51696649-51805890 (+)
C3H/HeJ MGP_C3HHeJ_G0033298
 protein coding gene Chr8:53620054-53732618 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034105
 protein coding gene Chr8:55729290-55841166 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031053
 protein coding gene Chr8:47326044-47425181 (+)
CAST/EiJ MGP_CASTEiJ_G0032624
 protein coding gene Chr8:53231772-53346718 (+)
CBA/J MGP_CBAJ_G0033277
 protein coding gene Chr8:57764573-57870290 (+)
DBA/2J MGP_DBA2J_G0033430
 protein coding gene Chr8:51269419-51376334 (+)
FVB/NJ MGP_FVBNJ_G0033371
 protein coding gene Chr8:50608486-50712493 (+)
LP/J MGP_LPJ_G0033518
 protein coding gene Chr8:53689209-53796811 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033415
 protein coding gene Chr8:58921095-59051620 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034123
 protein coding gene Chr8:53223004-53332248 (+)
PWK/PhJ MGP_PWKPhJ_G0032332
 protein coding gene Chr8:50798272-50900222 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032168
 protein coding gene Chr8:52292168-52393397 (+)
WSB/EiJ MGP_WSBEiJ_G0032740
 protein coding gene Chr8:53454267-53563220 (+)



Homology
more
  • Human Ortholog
    VEGFC, vascular endothelial growth factor C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VEGFC, vascular endothelial growth factor C
  • Synonyms
    Flt4-L, LMPH1D, LMPHM4, VRP
  • Links
    NCBI Gene ID: 7424
    neXtProt AC: NX_P49767
    UniProt: P49767

  • Chr Location
    4q34.3; chr4:176683538-176792922 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Vegfc mouse models; 2 with human VEGFC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this gene affects the development of the lymphatic system. Homozygous inactivation is embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    73
  • cDNA Data
    9
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22341 NCBI Gene Model | MGI Sequence Detail 108923 C57BL/6J ±  kb
    transcript NM_009506 RefSeq | MGI Sequence Detail 1881 Not Specified  
    polypeptide P97953 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 10
      Primer pair 9
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38168, MGI:2142780
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 71
      Diseases 1
      Gene Ontology 19
      Phenotypes 44
    • Earliest
      J:37681 Kukk E, et al., VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development. 1996 Dec;122(12):3829-37
    • Latest
      J:345357 Longtine C, et al., Homology and the evolution of vocal folds in the novel avian voice box. Curr Biol. 2024 Feb 5;34(3):461-472.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory