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Fzd5 Gene Detail
Summary
  • Symbol
    Fzd5
  • Name
    frizzled class receptor 5
  • Synonyms
    5330434N09Rik, Fz5
  • Feature Type
    protein coding gene
  • IDs
    MGI:108571
    NCBI Gene: 14367
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:64769717-64776907 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.74 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108571
 protein coding gene Chr1:64769717-64776910 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016098
 protein coding gene Chr1:64909607-64916831 (-)
A/J MGP_AJ_G0016081
 protein coding gene Chr1:62625353-62632548 (-)
AKR/J MGP_AKRJ_G0016038
 protein coding gene Chr1:64384584-64391777 (-)
BALB/cJ MGP_BALBcJ_G0016036
 protein coding gene Chr1:62721435-62728628 (-)
C3H/HeJ MGP_C3HHeJ_G0015868
 protein coding gene Chr1:64656527-64663722 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016489
 protein coding gene Chr1:67422214-67429407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014210
 protein coding gene Chr1:58686722-58693848 (-)
CAST/EiJ MGP_CASTEiJ_G0015451
 protein coding gene Chr1:63919499-63926694 (-)
CBA/J MGP_CBAJ_G0015840
 protein coding gene Chr1:69611698-69618891 (-)
DBA/2J MGP_DBA2J_G0015941
 protein coding gene Chr1:62031975-62039166 (-)
FVB/NJ MGP_FVBNJ_G0015944
 protein coding gene Chr1:61307851-61315052 (-)
LP/J MGP_LPJ_G0016013
 protein coding gene Chr1:65813641-65822099 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015964
 protein coding gene Chr1:72478458-72485653 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016536
 protein coding gene Chr1:64363233-64370428 (-)
PWK/PhJ MGP_PWKPhJ_G0015238
 protein coding gene Chr1:61423509-61430678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015017
 protein coding gene Chr1:63851083-63858318 (-)
WSB/EiJ MGP_WSBEiJ_G0015513
 protein coding gene Chr1:64070138-64077327 (-)



Homology
more
  • Human Ortholog
    FZD5, frizzled class receptor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD5, frizzled class receptor 5
  • Synonyms
    C2orf31, HFZ5, MCOPCB11
  • Links
    NCBI Gene ID: 7855
    neXtProt AC: NX_Q13467
    UniProt: Q13467

  • Chr Location
    2q33.3; chr2:207762598-207769906 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 5 alleles in 8 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal. Mice homozygous for another null allele exhibit abnormal eye development with increased apoptosis and decreased retinal proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1164
  • Tissues
    298
  • cDNA Data
    17
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14367 NCBI Gene Model | MGI Sequence Detail 7191 C57BL/6J ±  kb
    transcript NM_022721 RefSeq | MGI Sequence Detail 6912 ZRU/MplStud  
    polypeptide Q9EQD0 UniProt | EBI | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 19
      Primer pair 19
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37615, MGI:1925523, MGI:2138230
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 65
      Gene Ontology 20
      Phenotypes 28
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:360798 Mu Q, et al., FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response. Dev Cell. 2024 Nov 19;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory