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Cpeb1 Gene Detail
Summary
  • Symbol
    Cpeb1
  • Name
    cytoplasmic polyadenylation element binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108442
    NCBI Gene: 12877
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80996774-81105207 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2230 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108442
 protein coding gene Chr7:80996774-81105213 (-)
129S1/SvImJ ENSMUSG00200032095
 protein coding gene Chr7:67816304-67924045 (-)
A/J ENSMUSG00195036579
 protein coding gene Chr7:72240109-72347845 (-)
AKR/J ENSMUSG00220032315
 protein coding gene Chr7:65774979-65882695 (-)
BALB/cJ ENSMUSG00180013252
 protein coding gene Chr7:68958028-69065751 (-)
C3H/HeJ ENSMUSG00175021517
 protein coding gene Chr7:69728387-69836134 (-)
C57BL/6NJ ENSMUSG00215023186
 protein coding gene Chr7:68824431-68932176 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029919
 protein coding gene Chr7:83919293-84016801 (-)
CAST/EiJ ENSTCUG00005045062
 protein coding gene Chr7:72291296-72398469 (-)
CBA/J ENSMUSG00210023260
 protein coding gene Chr7:69579593-69687324 (-)
DBA/2J ENSMUSG00185046484
 protein coding gene Chr7:73902356-74010094 (-)
FVB/NJ ENSMUSG00205015063
 protein coding gene Chr7:69462238-69583760 (-)
JF1/MsJ ENSUMUG00000016757
 protein coding gene Chr7:78571945-78678959 (-)
LP/J ENSMUSG00230011060
 protein coding gene Chr7:79991631-80099366 (-)
NOD/ShiLtJ ENSMUSG00190016054
 protein coding gene Chr7:69719473-69827198 (-)
NZO/HlLtJ ENSMUSG00225041145
 protein coding gene Chr7:78239374-78345841 (-)
PWK/PhJ ENSLUMG00010017491
 protein coding gene Chr7:68167116-68274366 (-)
SPRET/EiJ ENSMSPG00010021195
 protein coding gene Chr7:68561533-68672007 (-)
WSB/EiJ ENSIUOG00005020250
 protein coding gene Chr7:70065717-70173440 (-)



Homology
more
  • Human Ortholog
    CPEB1, cytoplasmic polyadenylation element binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPEB1, cytoplasmic polyadenylation element binding protein 1
  • Synonyms
    CPEB, CPEB-1, CPE-BP1, h-CPEB, hCPEB-1
  • Links
    NCBI Gene ID: 64506
    UniProt: Q9BZB8

  • Chr Location
    15q25.2; chr15:82543201-82648861 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and overtly normal but display a developmental arrest of both female and male germ cells at the pachytene stage, defective synaptonemal complex formation, and impaired neuronal synaptic plasticity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    52
  • cDNA Data
    15
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12877 NCBI Gene Model | MGI Sequence Detail 108434 C57BL/6J ±  kb
    transcript NM_001412278 RefSeq | MGI Sequence Detail 3237 C57BL/6  
    polypeptide P70166 UniProt | EBI | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005805 cytoplasmic polyadenylation element-binding protein 1
      (term hierarchy)
    • InterPro Domains
      IPR038446 CEBP, ZZ domain superfamily
      IPR034977 CPEB-1, RNA recognition motif 1
      IPR034819 Cytoplasmic polyadenylation element-binding protein
      IPR032292 Cytoplasmic polyadenylation element-binding protein 1, N-terminal
      IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    • GlyGen
      P70166 1 site
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37486, MGI:2142147
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 16
      Gene Ontology 18
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:370108 Zhang J, et al., Cpeb1 remodels cell type-specific translational program to promote fear extinction. Sci Adv. 2025 Jan 10;11(2):eadr8687
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory