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Npy2r Gene Detail
Summary
  • Symbol
    Npy2r
  • Name
    neuropeptide Y receptor Y2
  • Synonyms
    NPY-Y2 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:108418
    NCBI Gene: 18167
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82445690-82455391 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 36.49 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108418
 protein coding gene Chr3:82445688-82455404 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027328
 protein coding gene Chr3:82349029-82358739 (-)
A/J MGP_AJ_G0027290
 protein coding gene Chr3:79627969-79638680 (-)
AKR/J MGP_AKRJ_G0027258
 protein coding gene Chr3:81520639-81530291 (-)
BALB/cJ MGP_BALBcJ_G0027301
 protein coding gene Chr3:79721663-79731315 (-)
C3H/HeJ MGP_C3HHeJ_G0027045
 protein coding gene Chr3:81798585-81808298 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027747
 protein coding gene Chr3:85454099-85463800 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025100
 protein coding gene Chr3:75379455-75388967 (-)
CAST/EiJ MGP_CASTEiJ_G0026492
 protein coding gene Chr3:81992192-82005180 (-)
CBA/J MGP_CBAJ_G0027020
 protein coding gene Chr3:88341865-88351578 (-)
DBA/2J MGP_DBA2J_G0027156
 protein coding gene Chr3:79186478-79196143 (-)
FVB/NJ MGP_FVBNJ_G0027124
 protein coding gene Chr3:77463737-77473520 (-)
LP/J MGP_LPJ_G0027264
 protein coding gene Chr3:83341125-83351246 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027143
 protein coding gene Chr3:94726144-94736233 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027805
 protein coding gene Chr3:81323996-81333658 (-)
PWK/PhJ MGP_PWKPhJ_G0026226
 protein coding gene Chr3:78923335-78933080 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026042
 protein coding gene Chr3:80516700-80525280 (-)
WSB/EiJ MGP_WSBEiJ_G0026570
 protein coding gene Chr3:81657475-81667142 (-)



Homology
more
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPY2R, neuropeptide Y receptor Y2
  • Synonyms
    NPY2-R
  • Links
    NCBI Gene ID: 4887
    neXtProt AC: NX_P49146
    UniProt: P49146

  • Chr Location
    4q32.1; chr4:155173723-155217078 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human NPY2R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 4 alleles in 7 genetic backgrounds
    43 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    899
  • Tissues
    124
  • cDNA Data
    8
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028004 Ensembl Gene Model | MGI Sequence Detail 9702 C57BL/6J ±  kb
    transcript ENSMUST00000098997 Ensembl | MGI Sequence Detail 3325 Not Applicable  
    polypeptide ENSMUSP00000096595 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 8
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37461
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 9
      Phenotypes 70
    • Earliest
      J:36684 Nakamura M, et al., Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim Biophys Acta. 1996 Oct 23;1284(2):134-7
    • Latest
      J:331502 Zahedi B, et al., The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass. Bone. 2022 Nov 8;167:116608
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory