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Gadd45b Gene Detail
Summary
  • Symbol
    Gadd45b
  • Name
    growth arrest and DNA-damage-inducible 45 beta
  • Synonyms
    Myd118
  • Feature Type
    protein coding gene
  • IDs
    MGI:107776
    NCBI Gene: 17873
  • Alliance
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80765925-80768038 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107776
protein coding gene Chr10:80765907-80768038 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017529
protein coding gene Chr10:81603724-81605837 (+)
A/J MGP_AJ_G0017507
protein coding gene Chr10:78723687-78725829 (+)
AKR/J MGP_AKRJ_G0017468
protein coding gene Chr10:80886019-80888132 (+)
BALB/cJ MGP_BALBcJ_G0017469
protein coding gene Chr10:78939520-78941633 (+)
C3H/HeJ MGP_C3HHeJ_G0017292
protein coding gene Chr10:80973557-80975670 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017923
protein coding gene Chr10:84402532-84404645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015612
protein coding gene Chr10:74933461-74935569 (+)
CAST/EiJ MGP_CASTEiJ_G0016859
protein coding gene Chr10:81206017-81208152 (+)
CBA/J MGP_CBAJ_G0017264
protein coding gene Chr10:87676924-87679037 (+)
DBA/2J MGP_DBA2J_G0017370
protein coding gene Chr10:77924200-77926313 (+)
FVB/NJ MGP_FVBNJ_G0017364
protein coding gene Chr10:77155979-77158092 (+)
LP/J MGP_LPJ_G0017441
protein coding gene Chr10:82056018-82064162 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017390
protein coding gene Chr10:89577529-89579642 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017964
protein coding gene Chr10:80876689-80880572 (+)
PWK/PhJ MGP_PWKPhJ_G0016640
protein coding gene Chr10:77818168-77820307 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016430
protein coding gene Chr10:79826209-79830075 (+)
WSB/EiJ MGP_WSBEiJ_G0016919
protein coding gene Chr10:80914283-80916401 (+)



Homology
more
  • Human Ortholog
    GADD45B, growth arrest and DNA damage inducible beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GADD45B, growth arrest and DNA damage inducible beta
  • Synonyms
    GADD45BETA, MYD118
  • Links
    NCBI Gene ID: 4616
    neXtProt AC: NX_O75293
    UniProt: O75293

  • Chr Location
    19p13.3; chr19:2476122-2478259 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus affects immune response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17873 NCBI Gene Model | MGI Sequence Detail 2114 C57BL/6J ±  kb
    transcript NM_008655 RefSeq | MGI Sequence Detail 1305 Not Specified  
    polypeptide P22339 UniProt | EBI | MGI Sequence Detail 160 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007788 growth arrest and DNA damage-inducible protein GADD45 beta
    • InterPro Domains
      IPR024824 Growth arrest and DNA damage-inducible protein GADD45
      IPR029064 Ribosomal protein eL30-like superfamily
      IPR004038 Ribosomal protein eL8/eL30/eS12/Gadd45
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 60
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36353, MGI:2143576
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 39
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:347497 Chathuranga WAG, et al., Gadd45beta is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation. Cell Rep. 2023 Nov 1;42(11):113358

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    05/28/2024
    MGI 6.13
    The Jackson Laboratory