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Myh9 Gene Detail
Summary
  • Symbol
    Myh9
  • Name
    myosin, heavy polypeptide 9, non-muscle
  • Synonyms
    D0Jmb2, E030044M24Rik, Fltn, Myhn1, Myhn-1, myosin IIA, NMHC II-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107717
    NCBI Gene: 17886
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:77644787-77726375 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107717
 protein coding gene Chr15:77644785-77726375 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022031
 protein coding gene Chr15:77894231-77975712 (-)
A/J MGP_AJ_G0021991
 protein coding gene Chr15:75194474-75277110 (-)
AKR/J MGP_AKRJ_G0021968
 protein coding gene Chr15:77272654-77355916 (-)
BALB/cJ MGP_BALBcJ_G0021999
 protein coding gene Chr15:75205838-75287289 (-)
C3H/HeJ MGP_C3HHeJ_G0021770
 protein coding gene Chr15:77353782-77439098 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022441
 protein coding gene Chr15:80961962-81044912 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019970
 protein coding gene Chr15:71770094-71850348 (-)
CAST/EiJ MGP_CASTEiJ_G0021290
 protein coding gene Chr15:77934252-78015651 (-)
CBA/J MGP_CBAJ_G0021735
 protein coding gene Chr15:83460807-83549283 (-)
DBA/2J MGP_DBA2J_G0021863
 protein coding gene Chr15:74689561-74772951 (-)
FVB/NJ MGP_FVBNJ_G0021842
 protein coding gene Chr15:73682023-73763836 (-)
LP/J MGP_LPJ_G0021932
 protein coding gene Chr15:78076734-78162667 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021862
 protein coding gene Chr15:88667430-88750100 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022455
 protein coding gene Chr15:77355030-77441785 (-)
PWK/PhJ MGP_PWKPhJ_G0021032
 protein coding gene Chr15:74670737-74753319 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020868
 protein coding gene Chr15:77126448-77207291 (-)
WSB/EiJ MGP_WSBEiJ_G0021343
 protein coding gene Chr15:77677141-77759764 (-)



Homology
more
  • Human Ortholog
    MYH9, myosin heavy chain 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH9, myosin heavy chain 9
  • Synonyms
    BDPLT6, DFNA17, EPSTS, FTNS, MATINS, MHA, NMHC-II-A, NMMHCA, NMMHC-IIA
  • Links
    NCBI Gene ID: 4627
    neXtProt AC: NX_P35579
    UniProt: P35579

  • Chr Location
    22q12.3; chr22:36281280-36388010 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Myh9 mouse models; 8 with human MYH9 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 15 alleles in 16 genetic backgrounds
    3 images
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance. Mice homozygous or heterozygous for one of several knock-in alleles exhibit macrothrombocytopenia, nephritis, cataracts and deafness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
DNA-templated transcription
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    76
  • cDNA Data
    179
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022443 Ensembl Gene Model | MGI Sequence Detail 81589 C57BL/6J ±  kb
    transcript ENSMUST00000016771 Ensembl | MGI Sequence Detail 7433 Not Applicable  
    polypeptide ENSMUSP00000016771 Ensembl | MGI Sequence Detail 1960 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      cDNA 179
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12745, MGD-MRK-12749, MGD-MRK-36293, MGI:1206575, MGI:1344335, MGI:2146296, MGI:2443228, MGI:97257
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 25
      Phenotypes 101
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:335266 Islam ST, et al., Nonmuscle Myosin IIA Regulates the Precise Alignment of Hexagonal Eye Lens Epithelial Cells During Fiber Cell Formation and Differentiation. Invest Ophthalmol Vis Sci. 2023 Apr 3;64(4):20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/21/2023
    MGI 6.22     		The Jackson Laboratory