Automated description from the Alliance of Genome Resources (Release 6.0.0)
Enables actin filament binding activity and protein domain specific binding activity. Involved in several processes, including cortical granule exocytosis; negative regulation of actin filament severing; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within several processes, including establishment of T cell polarity; microtubule cytoskeleton organization; and myoblast fusion. Located in several cellular components, including cortical granule; cytoskeleton; and immunological synapse. Part of myosin II complex. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; early embryo; heart and pericardium; salivary gland primordium; and sensory organ. Used to study MYH-9 related disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9).
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