Plcd4 MGI Mouse Gene Detail - MGI:107469 - phospholipase C, delta 4

Symbol

Plcd4
Name

phospholipase C, delta 4
Synonyms

4921507K24Rik

Feature Type

protein coding gene
IDs

MGI:107469
NCBI Gene: 18802
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:74581175-74605137 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.54 cM, cytoband C3-C5
Mapping Data

6 experiments

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107469	protein coding gene	Chr1:74581175-74606953 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016154	protein coding gene	Chr1:75151156-75176568 (+)
A/J	MGP_AJ_G0016137	protein coding gene	Chr1:72518079-72545287 (+)
AKR/J	MGP_AKRJ_G0016094	protein coding gene	Chr1:74532282-74557251 (+)
BALB/cJ	MGP_BALBcJ_G0016092	protein coding gene	Chr1:72585239-72611858 (+)
C3H/HeJ	MGP_C3HHeJ_G0015923	protein coding gene	Chr1:74869553-74895093 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016545	protein coding gene	Chr1:78070479-78096063 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014266	protein coding gene	Chr1:68099559-68125821 (+)
CAST/EiJ	MGP_CASTEiJ_G0015507	protein coding gene	Chr1:74195971-74220443 (+)
CBA/J	MGP_CBAJ_G0015896	protein coding gene	Chr1:80606289-80630921 (+)
DBA/2J	MGP_DBA2J_G0015997	protein coding gene	Chr1:71851474-71876230 (+)
FVB/NJ	MGP_FVBNJ_G0016000	protein coding gene	Chr1:71032944-71058165 (+)
LP/J	MGP_LPJ_G0016069	protein coding gene	Chr1:76257181-76282585 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016020	protein coding gene	Chr1:84009843-84035437 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016592	protein coding gene	Chr1:74598903-74624220 (+)
PWK/PhJ	MGP_PWKPhJ_G0015294	protein coding gene	Chr1:71306280-71332061 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015072	protein coding gene	Chr1:73974857-73999565 (+)
WSB/EiJ	MGP_WSBEiJ_G0015569	protein coding gene	Chr1:74404728-74431616 (+)

Human Ortholog

PLCD4, phospholipase C delta 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLCD4, phospholipase C delta 4
Links

HGNC:9062

NCBI Gene ID: 84812

neXtProt AC: NX_Q9BRC7

UniProt: Q9BRC7
Chr Location

2q35; chr2:218606873-218637186 (+) GRCh38.p7

Alliance of Genome Resources

Plcd4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PLCD4
Gene Tree

Plcd4

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Plcd4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for a targeted null mutation are subfertile or sterile. Sperm from mutant males fail to initiate the acrosome reaction.

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

102
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plcd4

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Plcd4 interacts with 326 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

73
RefSeq

24
UniProt

2
CCDS

CCDS35616.1, CCDS35617.1

Ensembl

ENSMUSG00000026173 (Evidence)
NCBI Gene

18802

			Length	Strain/Species	Flank
genomic	18802	NCBI Gene Model \| MGI Sequence Detail	23963	C57BL/6J	± kb
transcript	NM_148937	RefSeq \| MGI Sequence Detail	2981	Not Specified
polypeptide	Q8K3R3	UniProt \| EBI \| MGI Sequence Detail	807	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012834 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

(term hierarchy)
EC

3.1.4.11
InterPro Domains

IPR028387 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR011993 PH-like domain superfamily

IPR000909 Phosphatidylinositol-specific phospholipase C, X domain

IPR001192 Phosphoinositide phospholipase C family

IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain

IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain

IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 15

cDNA 13

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-35941, MGI:1922966

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Plcd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7433	Chr1:74580592-74580608 (+)	-575 bp
Tssr122	Chr1:74580618-74580625 (+)	-553 bp
Tssr7434	Chr1:74582020-74582036 (+)	853 bp
Tssr7435	Chr1:74582040-74582077 (+)	884 bp
Tssr7436	Chr1:74583504-74583526 (+)	2,340 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/17/2023 MGI 6.22