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Lag3 Gene Detail
Summary
  • Symbol
    Lag3
  • Name
    lymphocyte-activation gene 3
  • Synonyms
    CD223, LAG-3, Ly66
  • Feature Type
    protein coding gene
  • IDs
    MGI:106588
    NCBI Gene: 16768
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124881324-124888668 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106588
 protein coding gene Chr6:124881322-124888668 (-)
129S1/SvImJ ENSMUSG00200050997
 protein coding gene Chr6:121942688-121950032 (-)
A/J ENSMUSG00195044695
 protein coding gene Chr6:121395818-121403170 (-)
AKR/J ENSMUSG00220028995
 protein coding gene Chr6:120257403-120264757 (-)
BALB/cJ ENSMUSG00180048626
 protein coding gene Chr6:121734463-121741816 (-)
C3H/HeJ ENSMUSG00175039575
 protein coding gene Chr6:121395881-121402732 (-)
C57BL/6NJ ENSMUSG00215044796
 protein coding gene Chr6:121706424-121713768 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028860
 protein coding gene Chr6:120601328-120609407 (-)
CAST/EiJ ENSTCUG00005049665
 protein coding gene Chr6:121579870-121587269 (-)
CBA/J ENSMUSG00210039784
 protein coding gene Chr6:121434900-121442252 (-)
DBA/2J ENSMUSG00185038947
 protein coding gene Chr6:122134502-122141853 (-)
FVB/NJ ENSMUSG00205023197
 protein coding gene Chr6:120849257-120856608 (-)
JF1/MsJ ENSUMUG00000042627
 protein coding gene Chr6:120544145-120551532 (-)
LP/J ENSMUSG00230041792
 protein coding gene Chr6:123331400-123338751 (-)
NOD/ShiLtJ ENSMUSG00190048014
 protein coding gene Chr6:121106105-121113454 (-)
NZO/HlLtJ ENSMUSG00225015666
 protein coding gene Chr6:125354309-125361659 (-)
PWK/PhJ ENSLUMG00010044386
 protein coding gene Chr6:119811027-119818407 (-)
SPRET/EiJ ENSMSPG00010031657
 protein coding gene Chr6:122661606-122669095 (-)
WSB/EiJ ENSIUOG00005036838
 protein coding gene Chr6:121819534-121826888 (-)



Homology
more
  • Human Ortholog
    LAG3, lymphocyte activating 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAG3, lymphocyte activating 3
  • Synonyms
    CD223
  • Links
    NCBI Gene ID: 3902
    UniProt: P18627

  • Chr Location
    12p13.31; chr12:6772360-6778455 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a generally normal phenotype but do display reduced natural killer cell activity and increased T cell response to infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030124 Ensembl Gene Model | MGI Sequence Detail 7345 C57BL/6J ±  kb
    transcript ENSMUST00000032217 Ensembl | MGI Sequence Detail 2001 Not Applicable  
    polypeptide ENSMUSP00000032217 Ensembl | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35044
    References
    more
    • Summaries
      All 109
      Gene Ontology 20
      Phenotypes 51
    • Earliest
      J:32509 Miyazaki T, et al., Independent modes of natural killing distinguished in mice lacking Lag3. Science. 1996 Apr 19;272(5260):405-8
    • Latest
      J:385869 Perl AT, et al., Immune receptor LAG3 regulates microglia function during Alzheimer's disease. Neurobiol Dis. 2026 May 11;:107447
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory