Lag3 Phenotype Annotations

About Help FAQ

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lag3
lymphocyte-activation gene 3
MGI:106588

17 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lag3^tm1Daav/Lag3⁺ Tg(Foxp3-EGFP/cre)1cJbs/0 NOD.Cg-Lag3^tm1Daav Tg(Foxp3-EGFP/cre)1cJbs	decreased susceptibility to autoimmune diabetes	J:260063
Lag3^tm1Daav/Lag3^tm1Daav Tg(Foxp3-EGFP/cre)1cJbs/0 NOD.Cg-Lag3^tm1Daav Tg(Foxp3-EGFP/cre)1cJbs	abnormal CD8-positive, alpha-beta T cell physiology	J:260063
	abnormal effector T cell number	J:260063
	abnormal interleukin level	J:260063
	abnormal tumor necrosis factor level	J:260063
	decreased susceptibility to autoimmune diabetes	J:260063
Lag3^tm1Doi/Lag3^tm1Doi involves: 129S2/SvPas * C57BL/6	abnormal dopamine level	J:235638
	abnormal dopaminergic neuron morphology	J:235638
	abnormal grip strength	J:235638
	abnormal NK cell physiology	J:32509
	abnormal reflex	J:235638
	abnormal T cell physiology	J:89653
	alpha-synuclein inclusion body	J:235638
	decreased tumor growth/size	J:269578
	enlarged spleen	J:89653
	increased CD4-positive, alpha-beta T cell number	J:89653
	increased CD8-positive, alpha-beta T cell number	J:89653
	increased single-positive T cell number	J:89653

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23