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Spock1 Gene Detail
Summary
  • Symbol
    Spock1
  • Name
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
  • Synonyms
    testican 1, Ticn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105371
    NCBI Gene: 20745
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:57569008-58056146 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.50 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105371
protein coding gene Chr13:57569008-58056194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020625
protein coding gene Chr13:57011217-57514511 (-)
A/J MGP_AJ_G0020579
protein coding gene Chr13:54895244-55386911 (-)
AKR/J MGP_AKRJ_G0020557
protein coding gene Chr13:56512708-57013575 (-)
BALB/cJ MGP_BALBcJ_G0020575
protein coding gene Chr13:55140590-55629216 (-)
C3H/HeJ MGP_C3HHeJ_G0020374
protein coding gene Chr13:56335610-56833269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021009
protein coding gene Chr13:58764674-59280541 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018591
protein coding gene Chr13:52813972-53302941 (-)
CAST/EiJ MGP_CASTEiJ_G0019888
protein coding gene Chr13:56437520-56960812 (-)
CBA/J MGP_CBAJ_G0020334
protein coding gene Chr13:60988530-61515205 (-)
DBA/2J MGP_DBA2J_G0020457
protein coding gene Chr13:54442045-54931822 (-)
FVB/NJ MGP_FVBNJ_G0020436
protein coding gene Chr13:53913932-54404581 (-)
LP/J MGP_LPJ_G0020533
protein coding gene Chr13:57281577-57793250 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020465
protein coding gene Chr13:60384438-60888571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021052
protein coding gene Chr13:56129860-56628465 (-)
PWK/PhJ MGP_PWKPhJ_G0019644
protein coding gene Chr13:54401594-54922894 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019471
protein coding gene Chr13:55041148-55545364 (-)
WSB/EiJ MGP_WSBEiJ_G0019950
protein coding gene Chr13:56511718-57017986 (-)



Homology
more
  • Human Ortholog
    SPOCK1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPOCK1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
  • Synonyms
    SPOCK, TESTICAN, TIC1
  • Links
    NCBI Gene ID: 6695
    neXtProt AC: NX_Q08629
    UniProt: Q08629

  • Chr Location
    5q31.2; chr5:136975298-137598379 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SPOCK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation display no obvious morphological or behavioral abnormalities, are fertile, and have normal life spans. Adult homozygotes exhibit normal brain morphology and EEG recordings.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056222 Ensembl Gene Model | MGI Sequence Detail 487139 C57BL/6J ±  kb
    transcript ENSMUST00000185502 Ensembl | MGI Sequence Detail 4614 Not Applicable  
    polypeptide ENSMUSP00000140409 Ensembl | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 42
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33040
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 16
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/28/2024
    MGI 6.13
    The Jackson Laboratory