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Gclm Gene Detail
Summary
  • Symbol
    Gclm
  • Name
    glutamate-cysteine ligase, modifier subunit
  • Synonyms
    Gcmc, Glclr
  • Feature Type
    protein coding gene
  • IDs
    MGI:104995
    NCBI Gene: 14630
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:122039206-122060864 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 52.94 cM, cytoband H1-3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    469 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104995
 protein coding gene Chr3:122039206-122064381 (+)
129S1/SvImJ ENSMUSG00200024786
 protein coding gene Chr3:118725107-118750291 (+)
A/J ENSMUSG00195015273
 protein coding gene Chr3:118942224-118967399 (+)
AKR/J ENSMUSG00220024168
 protein coding gene Chr3:117329223-117354397 (+)
BALB/cJ ENSMUSG00180027002
 protein coding gene Chr3:118878713-118903888 (+)
C3H/HeJ ENSMUSG00175025532
 protein coding gene Chr3:118425506-118450683 (+)
C57BL/6NJ ENSMUSG00215006385
 protein coding gene Chr3:119173705-119198882 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025592
 protein coding gene Chr3:115761542-115785798 (+)
CAST/EiJ ENSTCUG00005029030
 protein coding gene Chr3:119449363-119474402 (+)
CBA/J ENSMUSG00210002830
 protein coding gene Chr3:119056437-119081612 (+)
DBA/2J ENSMUSG00185006986
 protein coding gene Chr3:119622022-119646956 (+)
FVB/NJ ENSMUSG00205006922
 protein coding gene Chr3:117993227-118018401 (+)
JF1/MsJ ENSUMUG00000002319
 protein coding gene Chr3:118427630-118452564 (+)
LP/J ENSMUSG00230011223
 protein coding gene Chr3:121575712-121600895 (+)
NOD/ShiLtJ ENSMUSG00190026755
 protein coding gene Chr3:120004290-120029464 (+)
NZO/HlLtJ ENSMUSG00225002682
 protein coding gene Chr3:124063211-124088385 (+)
PWK/PhJ ENSLUMG00010009127
 protein coding gene Chr3:118404687-118429618 (+)
SPRET/EiJ ENSMSPG00010025954
 protein coding gene Chr3:119154821-119178743 (+)
WSB/EiJ ENSIUOG00005006803
 protein coding gene Chr3:119224843-119250018 (+)



Homology
more
  • Human Ortholog
    GCLM, glutamate-cysteine ligase modifier subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCLM, glutamate-cysteine ligase modifier subunit
  • Synonyms
    GLCLR
  • Links
    NCBI Gene ID: 2730
    UniProt: P48507

  • Chr Location
    1p22.1; chr1:93885199-93909513 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GCLM associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 5 genetic backgrounds
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one null allele show reduced cysteine levels and increased cellular sensitivity to hydrogen peroxide. Homozygotes for another null allele show increased sensitivity to induced hepatotoxicity and neurotoxicity, and ovarian oxidative stress and accelerated ovarian failure in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    153
  • cDNA Data
    11
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14630 NCBI Gene Model | MGI Sequence Detail 21659 C57BL/6J ±  kb
    transcript NM_008129 RefSeq | MGI Sequence Detail 2072 ZRU/MplStud  
    polypeptide O09172 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000007898 glutamate--cysteine ligase regulatory subunit
      (term hierarchy)
    • InterPro Domains
      IPR032963 Glutamate--cysteine ligase regulatory subunit
      IPR023210 NADP-dependent oxidoreductase domain
      IPR036812 NAD(P)-dependent oxidoreductase domain superfamily
    • GlyGen
      O09172 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 12
      Primer pair 4
      Antibodies 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-31068, MGI:2139773
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 12
      Phenotypes 62
    • Earliest
      J:30588 Tsuchiya K, et al., Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995 Dec 10;30(3):630-2
    • Latest
      J:368023 He J, et al., Nrf2 Regulates Basal Glutathione Production in Astrocytes. Int J Mol Sci. 2025 Jan 15;26(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory