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Ier2 Gene Detail
Summary
  • Symbol
    Ier2
  • Name
    immediate early response 2
  • Synonyms
    ch1, pip92
  • Feature Type
    protein coding gene
  • IDs
    MGI:104815
    NCBI Gene: 15936
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85387960-85389481 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104815
 protein coding gene Chr8:85387960-85389483 (-)
129S1/SvImJ ENSMUSG00200025372
 protein coding gene Chr8:79752959-79754480 (-)
A/J ENSMUSG00195014155
 protein coding gene Chr8:80110968-80112489 (-)
AKR/J ENSMUSG00220021335
 protein coding gene Chr8:80152495-80154016 (-)
BALB/cJ ENSMUSG00180018694
 protein coding gene Chr8:79951639-79953160 (-)
C3H/HeJ ENSMUSG00175010576
 protein coding gene Chr8:80046665-80048186 (-)
C57BL/6NJ ENSMUSG00215007883
 protein coding gene Chr8:79684113-79685636 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031302
 protein coding gene Chr8:75996762-75998273 (-)
CAST/EiJ ENSTCUG00005031562
 protein coding gene Chr8:79561219-79562743 (-)
CBA/J ENSMUSG00210019859
 protein coding gene Chr8:80033791-80035312 (-)
DBA/2J ENSMUSG00185036215
 protein coding gene Chr8:86142376-86143897 (-)
FVB/NJ ENSMUSG00205016959
 protein coding gene Chr8:79089611-79091132 (-)
JF1/MsJ ENSUMUG00000010448
 protein coding gene Chr8:88450687-88452210 (-)
LP/J ENSMUSG00230027156
 protein coding gene Chr8:89749975-89751496 (-)
NOD/ShiLtJ ENSMUSG00190025275
 protein coding gene Chr8:80107928-80109448 (-)
NZO/HlLtJ ENSMUSG00225039591
 protein coding gene Chr8:93144830-93146353 (-)
PWK/PhJ ENSLUMG00010027236
 protein coding gene Chr8:79788285-79789808 (-)
SPRET/EiJ ENSMSPG00010023914
 protein coding gene Chr8:81703813-81705323 (-)
WSB/EiJ ENSIUOG00005015469
 protein coding gene Chr8:80848266-80849787 (-)



Homology
more
  • Human Ortholog
    IER2, immediate early response 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IER2, immediate early response 2
  • Synonyms
    CHX1, ETR101
  • Links
    NCBI Gene ID: 9592
    UniProt: Q9BTL4

  • Chr Location
    19p13.13; chr19:13150411-13156981 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IER2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Ier2
  • Find Mice (IMSR)
    10 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    16
  • cDNA Data
    157
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15936 NCBI Gene Model | MGI Sequence Detail 1522 C57BL/6J ±  kb
transcript NM_010499 RefSeq | MGI Sequence Detail 1541 ZRU/MplStud  
polypeptide P17950 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 160
    Genomic 1
    cDNA 157
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28109, MGI:2142503
References
more
  • Summaries
    All 72
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 36
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory