Tle3 MGI Mouse Gene Detail - MGI:104634 - transducin-like enhancer of split 3

Symbol

Tle3
Name

transducin-like enhancer of split 3
Synonyms

2610103N05Rik, ESG, Grg3a, Grg3b, mKIAA1547

Feature Type

protein coding gene
IDs

MGI:104634
NCBI Gene: 21887
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:61279648-61325779 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 33.27 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

270 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104634	protein coding gene	Chr9:61279608-61325779 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034914	protein coding gene	Chr9:60832551-60881529 (+)
A/J	MGP_AJ_G0034894	protein coding gene	Chr9:58858505-58904677 (+)
AKR/J	MGP_AKRJ_G0034824	protein coding gene	Chr9:60221124-60267242 (+)
BALB/cJ	MGP_BALBcJ_G0034887	protein coding gene	Chr9:58577061-58623196 (+)
C3H/HeJ	MGP_C3HHeJ_G0034597	protein coding gene	Chr9:60710065-60756196 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035406	protein coding gene	Chr9:62479481-62525621 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032317	protein coding gene	Chr9:58552101-58598496 (+)
CAST/EiJ	MGP_CASTEiJ_G0033918	protein coding gene	Chr9:60821084-60869697 (+)
CBA/J	MGP_CBAJ_G0034568	protein coding gene	Chr9:64637133-64683256 (+)
DBA/2J	MGP_DBA2J_G0034727	protein coding gene	Chr9:58658809-58704860 (+)
FVB/NJ	MGP_FVBNJ_G0034669	protein coding gene	Chr9:57940098-57986245 (+)
LP/J	MGP_LPJ_G0034810	protein coding gene	Chr9:61126254-61174451 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034712	protein coding gene	Chr9:66101485-66147616 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035428	protein coding gene	Chr9:60262971-60309113 (+)
PWK/PhJ	MGP_PWKPhJ_G0033622	protein coding gene	Chr9:58755247-58820573 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033455	protein coding gene	Chr9:60544000-60638072 (+)
WSB/EiJ	MGP_WSBEiJ_G0034031	protein coding gene	Chr9:60180665-60226945 (+)

Human Ortholog

TLE3, TLE family member 3, transcriptional corepressor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLE3, TLE family member 3, transcriptional corepressor
Synonyms

ESG, ESG3, GRG3, HsT18976
Links

HGNC:11839

NCBI Gene ID: 7090

neXtProt AC: NX_Q04726

UniProt: Q04726
Chr Location

15q23; chr15:70047790-70098176 (-) GRCh38

Alliance of Genome Resources

Tle3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TLE3
Gene Tree

Tle3

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Phenotype Summary

33 phenotypes from 4 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homzoygous for a gene trap allele exhibit embryonic lethality.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1101
Tissues

280
cDNA Data

134
Literature Summary

44

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tle3a, tle3b

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Tle3 interacts with 208 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

116
RefSeq

29
UniProt

14
CCDS

CCDS52824.1, CCDS52825.1, CCDS52826.1

Ensembl

ENSMUSG00000032280 (Evidence)
NCBI Gene

21887

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032280	Ensembl Gene Model \| MGI Sequence Detail	46132	C57BL/6J	± kb
transcript	ENSMUST00000178113	Ensembl \| MGI Sequence Detail	5205	Not Applicable
polypeptide	ENSMUSP00000136010	Ensembl \| MGI Sequence Detail	783	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000016374 transducin-like enhancer protein 3

(term hierarchy)
InterPro Domains

IPR005617 Groucho/TLE, N-terminal Q-rich domain

IPR009146 Groucho/transducin-like enhancer

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 142

cDNA 136

Primer pair 5

Other 1

Microarray probesets 5

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MGD-MRK-26071, MGI:1917582

Summaries

All 91

Developmental Gene Expression 44

Gene Ontology 6

Phenotypes 13
Earliest

J:14582 Miyasaka H, et al., Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. Eur J Biochem. 1993 Aug 15;216(1):343-52
Latest

J:334460 Bando H, et al., Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. Hum Mol Genet. 2023 Jan 13;32(3):367-385

TSS for Tle3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85504	Chr9:61279591-61279602 (+)	-51 bp
Tssr85505	Chr9:61279641-61279665 (+)	5 bp
Tssr85506	Chr9:61279670-61279686 (+)	30 bp
Tssr85507	Chr9:61279747-61279760 (+)	106 bp
Tssr85508	Chr9:61280634-61280673 (+)	1,006 bp
Tssr85509	Chr9:61280787-61280803 (+)	1,147 bp
Tssr85510	Chr9:61280890-61280932 (+)	1,263 bp
Tssr85511	Chr9:61299150-61299159 (+)	19,507 bp
Tssr85512	Chr9:61325091-61325099 (+)	45,447 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22