Tle3 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tle3
transducin-like enhancer of split 3
MGI:104634

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Tle2^{tm1(KOMP)Vlcg}/Tle2^{tm1(KOMP)Vlcg} Tle3^tm1.1Pton/Tle3^tm1.1Pton Tg(Pdx1-cre)6Tuv/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	decreased pancreatic beta cell number	J:307817
	impaired glucose tolerance	J:307817
Tle3^tm1.1Pton/Tle3^tm1.1Pton Tle4^tm1.1Dasw/Tle4^tm1.1Dasw Tg(Pdx1-cre)6Tuv/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal pancreas development	J:307817
	abnormal pancreatic beta cell differentiation	J:307817
	abnormal pancreatic islet morphology	J:307817
	decreased pancreatic beta cell mass	J:307817
	decreased pancreatic beta cell number	J:307817
	decreased pancreatic beta cell proliferation	J:307817
	disorganized pancreatic islets	J:307817
	normal growth/size/body region phenotype	J:307817
	hyperglycemia	J:307817
	impaired glucose tolerance	J:307817
	postnatal lethality, incomplete penetrance	J:307817

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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