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Hcls1 Gene Detail
Summary
  • Symbol
    Hcls1
  • Name
    hematopoietic cell specific Lyn substrate 1
  • Synonyms
    HS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104568
    NCBI Gene: 15163
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36755345-36783574 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.30 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104568
protein coding gene Chr16:36755345-36783576 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022796
protein coding gene Chr16:35357699-35386716 (+)
A/J MGP_AJ_G0022761
protein coding gene Chr16:33615786-33643927 (+)
AKR/J MGP_AKRJ_G0022733
protein coding gene Chr16:34899331-34928212 (+)
BALB/cJ MGP_BALBcJ_G0022762
protein coding gene Chr16:33719364-33747713 (+)
C3H/HeJ MGP_C3HHeJ_G0022526
protein coding gene Chr16:35016236-35045937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023209
protein coding gene Chr16:36199596-36228683 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020723
protein coding gene Chr16:33979893-34008215 (+)
CAST/EiJ MGP_CASTEiJ_G0022052
protein coding gene Chr16:35137890-35171331 (+)
CBA/J MGP_CBAJ_G0022497
protein coding gene Chr16:37778746-37806934 (+)
DBA/2J MGP_DBA2J_G0022629
protein coding gene Chr16:33511393-33539493 (+)
FVB/NJ MGP_FVBNJ_G0022604
protein coding gene Chr16:33541580-33569729 (+)
LP/J MGP_LPJ_G0022697
protein coding gene Chr16:35064604-35091223 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022623
protein coding gene Chr16:36836043-36868835 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023224
protein coding gene Chr16:34847571-34876644 (+)
PWK/PhJ MGP_PWKPhJ_G0021792
protein coding gene Chr16:33912639-33941311 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021623
protein coding gene Chr16:34765442-34794630 (+)
WSB/EiJ MGP_WSBEiJ_G0022096
protein coding gene Chr16:34904784-34935566 (+)



Homology
more
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
  • Synonyms
    CTTNL, HS1, lckBP1, p75
  • Links
    NCBI Gene ID: 3059
    neXtProt AC: NX_P14317
    UniProt: P14317

  • Chr Location
    3q13.33; chr3:121631399-121660927 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022831 Ensembl Gene Model | MGI Sequence Detail 28230 C57BL/6J ±  kb
    transcript ENSMUST00000023531 Ensembl | MGI Sequence Detail 2016 Not Applicable  
    polypeptide ENSMUSP00000023531 Ensembl | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 4
      cDNA 43

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26002, MGI:2146629
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:16376 Fukamachi H, et al., Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol. 1994 Jan 15;152(2):642-52
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory