Meox2 MGI Mouse Gene Detail - MGI:103219

Symbol

Meox2
Name

mesenchyme homeobox 2
Synonyms

Gax, Mox2, Mox-2

Feature Type

protein coding gene
IDs

MGI:103219
NCBI Gene: 17286
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:37158539-37229533 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 16.84 cM
Mapping Data

7 experiments

SNPs within 2kb

653 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103219	protein coding gene	Chr12:37158539-37229533 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019695	protein coding gene	Chr12:35379885-35448343 (+)
A/J	MGP_AJ_G0019661	protein coding gene	Chr12:34259206-34320161 (+)
AKR/J	MGP_AKRJ_G0019632	protein coding gene	Chr12:35301958-35365825 (+)
BALB/cJ	MGP_BALBcJ_G0019639	protein coding gene	Chr12:34465844-34526328 (+)
C3H/HeJ	MGP_C3HHeJ_G0019443	protein coding gene	Chr12:35254651-35317213 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020086	protein coding gene	Chr12:36371865-36447757 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017710	protein coding gene	Chr12:33351172-33411191 (+)
CAST/EiJ	MGP_CASTEiJ_G0018996	protein coding gene	Chr12:30326870-30396147 (+)
CBA/J	MGP_CBAJ_G0019415	protein coding gene	Chr12:37573742-37644385 (+)
DBA/2J	MGP_DBA2J_G0019528	protein coding gene	Chr12:34111011-34172717 (+)
FVB/NJ	MGP_FVBNJ_G0019517	protein coding gene	Chr12:33817556-33879609 (+)
LP/J	MGP_LPJ_G0019598	protein coding gene	Chr12:35465906-35537744 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019553	protein coding gene	Chr12:37338736-37444530 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020126	protein coding gene	Chr12:34831427-34903030 (+)
PWK/PhJ	MGP_PWKPhJ_G0018763	protein coding gene	Chr12:28798152-28859536 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018553	protein coding gene	Chr12:29497579-29566137 (+)
WSB/EiJ	MGP_WSBEiJ_G0019046	protein coding gene	Chr12:35106603-35175417 (+)

Human Ortholog

MEOX2, mesenchyme homeobox 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEOX2, mesenchyme homeobox 2
Synonyms

GAX, MOX2
Links

HGNC:7014

NCBI Gene ID: 4223

neXtProt AC: NX_P50222

UniProt: P50222
Chr Location

7p21.2; chr7:15611212-15686683 (-) GRCh38

MGI Vertebrate Homology

Meox2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MEOX2
Gene Tree

Meox2

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Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
249 phenotypes from multigenic genotypes
6 images
319 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Several mutations that inactivate the gene result in mild defects of rib and vertebrae development. Inactivation in conjunction with a null mutation in a related homeobox gene results in more severe defects stemming from impaired somite formation, patterning, and differentiation.

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All GO Annotations

28
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1240
Tissues

243
cDNA Data

34
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MEOX2

Xenbase meox2

ZFIN meox2a, meox2b

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS25888.1

Ensembl

ENSMUSG00000036144 (Evidence)
NCBI Gene

17286

			Length	Strain/Species	Flank
genomic	17286	NCBI Gene Model \| MGI Sequence Detail	70995	C57BL/6J	± kb
transcript	NM_008584	RefSeq \| MGI Sequence Detail	2360	ZRU/MplStud
polypeptide	P32443	UniProt \| EBI \| MGI Sequence Detail	303	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010323 homeobox protein MOX-2

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR042634 Homeobox protein MOX-1/MOX-2

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All nucleic 50

Genomic 2

cDNA 37

Primer pair 9

Other 2

Microarray probesets 4

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MGD-MRK-12395, MGD-MRK-12397, MGD-MRK-24089, MGI:2144856

Summaries

All 393

Developmental Gene Expression 45

Diseases 2

Gene Ontology 11

Phenotypes 319
Earliest

J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
Latest

J:344941 Yan F, et al., Single-cell multiomics decodes regulatory programs for mouse secondary palate development. Nat Commun. 2024 Jan 27;15(1):821

TSS for Meox2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113247	Chr12:37158532-37158545 (+)	0 bp
Tssr113248	Chr12:37158553-37158606 (+)	41 bp
Tssr113249	Chr12:37158615-37158630 (+)	84 bp
Tssr113250	Chr12:37158631-37158642 (+)	98 bp
Tssr113251	Chr12:37158660-37158672 (+)	127 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23