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Sod3 Gene Detail
Summary
  • Symbol
    Sod3
  • Name
    superoxide dismutase 3, extracellular
  • Synonyms
    EC-SOD, MGC:13799
  • Feature Type
    protein coding gene
  • IDs
    MGI:103181
    NCBI Gene: 20657
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:52521146-52527080 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 27.92 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103181
 protein coding gene Chr5:52521133-52528760 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029544
 protein coding gene Chr5:51334839-51342707 (+)
A/J MGP_AJ_G0029512
 protein coding gene Chr5:49546979-49554605 (+)
AKR/J MGP_AKRJ_G0029460
 protein coding gene Chr5:51214486-51222171 (+)
BALB/cJ MGP_BALBcJ_G0029521
 protein coding gene Chr5:50012045-50019683 (+)
C3H/HeJ MGP_C3HHeJ_G0029244
 protein coding gene Chr5:51382166-51389860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029975
 protein coding gene Chr5:53472655-53480341 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027215
 protein coding gene Chr5:46318258-46325950 (+)
CAST/EiJ MGP_CASTEiJ_G0028652
 protein coding gene Chr5:50389257-50397541 (+)
CBA/J MGP_CBAJ_G0029213
 protein coding gene Chr5:55106855-55117100 (+)
DBA/2J MGP_DBA2J_G0029359
 protein coding gene Chr5:49597455-49605849 (+)
FVB/NJ MGP_FVBNJ_G0029319
 protein coding gene Chr5:48939433-48947056 (+)
LP/J MGP_LPJ_G0029444
 protein coding gene Chr5:51797280-51806062 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029347
 protein coding gene Chr5:56208626-56217042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030008
 protein coding gene Chr5:50708000-50715607 (+)
PWK/PhJ MGP_PWKPhJ_G0028376
 protein coding gene Chr5:48662719-48670682 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028210
 protein coding gene Chr5:50159595-50167245 (+)
WSB/EiJ MGP_WSBEiJ_G0028733
 protein coding gene Chr5:50754413-50763053 (+)



Homology
more
  • Human Ortholog
    SOD3, superoxide dismutase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOD3, superoxide dismutase 3
  • Synonyms
    EC-SOD
  • Links
    NCBI Gene ID: 6649
    UniProt: P08294

  • Chr Location
    4p15.2; chr4:24789912-24800842 (+)  GRCh38
Human Diseases
more
  • Diseases
    10 with human SOD3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 4 genetic backgrounds
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to hyperoxia, increased LPS-stimulated spleen production of TNF, and enhanced severity of collagen-induced arthritis. A substitution in the extracellular matrix-binding domain causes redistribution of the expressed peptide to extracellular fluids, increasing cardiovascular disease risk but reducing lung disease risk.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1017
  • Tissues
    242
  • cDNA Data
    82
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20657 NCBI Gene Model | MGI Sequence Detail 5935 C57BL/6J ±  kb
    transcript NM_011435 RefSeq | MGI Sequence Detail 2045 C57BL/6 x CBA  
    polypeptide O09164 UniProt | EBI | MGI Sequence Detail 251 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015401 extracellular superoxide dismutase [Cu-Zn]
      (term hierarchy)
    • EC
      1.15.1.1
    • InterPro Domains
      IPR001424 Superoxide dismutase, copper/zinc binding domain
      IPR018152 Superoxide dismutase, copper/zinc, binding site
      IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
      IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamily
    • GlyGen
      O09164 1 site, 15 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 89
      Genomic 1
      cDNA 83
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24049, MGI:2140829
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 86
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:352715 Kang HS, et al., GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. Cell Mol Life Sci. 2024 Jan 28;81(1):65
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory