Mtnr1a MGI Mouse Gene Detail - MGI:102967

Symbol

Mtnr1a
Name

melatonin receptor 1A
Synonyms

Mel1a receptor, MelR

Feature Type

protein coding gene
IDs

MGI:102967
NCBI Gene: 17773
Alliance

gene page

Sequence Map

Chr8:45522174-45541543 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 24.95 cM
Mapping Data

4 experiments

SNPs within 2kb

209 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102967	protein coding gene	Chr8:45522144-45542270 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033571	protein coding gene	Chr8:44089162-44108579 (+)
A/J	MGP_AJ_G0033553	protein coding gene	Chr8:42406211-42426226 (+)
AKR/J	MGP_AKRJ_G0033478	protein coding gene	Chr8:43650064-43670225 (+)
BALB/cJ	MGP_BALBcJ_G0033550	protein coding gene	Chr8:42569476-42591211 (+)
C3H/HeJ	MGP_C3HHeJ_G0033259	protein coding gene	Chr8:44152075-44171260 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034066	protein coding gene	Chr8:45765319-45785807 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031015	protein coding gene	Chr8:38696787-38716545 (+)
CAST/EiJ	MGP_CASTEiJ_G0032585	protein coding gene	Chr8:43583915-43603881 (+)
CBA/J	MGP_CBAJ_G0033238	protein coding gene	Chr8:47615012-47636642 (+)
DBA/2J	MGP_DBA2J_G0033391	protein coding gene	Chr8:42220496-42239435 (+)
FVB/NJ	MGP_FVBNJ_G0033332	protein coding gene	Chr8:41719506-41738461 (+)
LP/J	MGP_LPJ_G0033479	protein coding gene	Chr8:44116889-44136857 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033377	protein coding gene	Chr8:47704581-47723559 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034084	protein coding gene	Chr8:43804368-43823311 (+)
PWK/PhJ	MGP_PWKPhJ_G0032293	protein coding gene	Chr8:41743519-41763082 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032129	protein coding gene	Chr8:42970236-42988951 (+)
WSB/EiJ	MGP_WSBEiJ_G0032701	protein coding gene	Chr8:44055825-44075978 (+)

Human Ortholog

MTNR1A, melatonin receptor 1A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTNR1A, melatonin receptor 1A
Synonyms

MEL-1A-R, MT1
Links

HGNC:7463

NCBI Gene ID: 4543

neXtProt AC: NX_P48039

UniProt: P48039
Chr Location

4q35.2; chr4:186526792-186555567 (-) GRCh38

MGI Vertebrate Homology

Mtnr1a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MTNR1A
Gene Tree

Mtnr1a

less

Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

3
Genomic Mutations

1 involving Mtnr1a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are essentially normal, with normal circadian functions. In vitro studies report the absence of inhibitory effects of melatonin on suprachiasma neuronal firing.

less

All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

63
cDNA Data

6
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtnr1a

ZFIN mtnr1aa, mtnr1ab

less

All Sequences

43
RefSeq

10
UniProt

4
CCDS

CCDS22273.1

Ensembl

ENSMUSG00000054764 (Evidence)
NCBI Gene

17773

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054764	Ensembl Gene Model \| MGI Sequence Detail	19370	C57BL/6J	± kb
transcript	ENSMUST00000067984	Ensembl \| MGI Sequence Detail	1576	Not Applicable
polypeptide	ENSMUSP00000069872	Ensembl \| MGI Sequence Detail	353	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000001609 melatonin receptor type 1A

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR002278 Melatonin receptor 1A/1B

IPR000025 Melatonin receptor family

less

All nucleic 14

Genomic 4

cDNA 6

Primer pair 3

Other 1

Microarray probesets 3

less

MGD-MRK-23804

Summaries

All 73

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 39
Earliest

J:26189 Slaugenhaupt SA, et al., Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 1995 May 20;27(2):355-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23