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Cpe Gene Detail
Summary
  • Symbol
    Cpe
  • Name
    carboxypeptidase E
  • Synonyms
    carboxypeptidase H, CPH, Cph-1, Cph1, NF-alpha1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101932
    NCBI Gene: 12876
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:65045576-65146088 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 32.30 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3353 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101932
 protein coding gene Chr8:65045576-65146143 (-)
129S1/SvImJ ENSMUSG00200006920
 protein coding gene Chr8:59877995-59978515 (-)
A/J ENSMUSG00195012061
 protein coding gene Chr8:60238696-60340117 (-)
AKR/J ENSMUSG00220005264
 protein coding gene Chr8:60070911-60172354 (-)
BALB/cJ ENSMUSG00180014120
 protein coding gene Chr8:59862195-59963632 (-)
C3H/HeJ ENSMUSG00175007333
 protein coding gene Chr8:60087120-60188553 (-)
C57BL/6NJ ENSMUSG00215007180
 protein coding gene Chr8:59869607-59970125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031084
 protein coding gene Chr8:56922992-57024872 (-)
CAST/EiJ ENSTCUG00005006460
 protein coding gene Chr8:59691086-59791781 (-)
CBA/J ENSMUSG00210009001
 protein coding gene Chr8:59968092-60069520 (-)
DBA/2J ENSMUSG00185022094
 protein coding gene Chr8:66020953-66122376 (-)
FVB/NJ ENSMUSG00205010168
 protein coding gene Chr8:59319508-59420038 (-)
JF1/MsJ ENSUMUG00000007449
 protein coding gene Chr8:68285116-68385700 (-)
LP/J ENSMUSG00230005643
 protein coding gene Chr8:69679631-69781054 (-)
NOD/ShiLtJ ENSMUSG00190009593
 protein coding gene Chr8:59845124-59946520 (-)
NZO/HlLtJ ENSMUSG00225045524
 protein coding gene Chr8:73098551-73199366 (-)
PWK/PhJ ENSLUMG00010012501
 protein coding gene Chr8:59756606-59865227 (-)
SPRET/EiJ ENSMSPG00010039411
 protein coding gene Chr8:61014543-61112387 (-)
WSB/EiJ ENSIUOG00005016204
 protein coding gene Chr8:60770537-60872106 (-)



Homology
more
  • Human Ortholog
    CPE, carboxypeptidase E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPE, carboxypeptidase E
  • Synonyms
    BDVS, CPH, IDDHH
  • Links
    NCBI Gene ID: 1363
    UniProt: P16870

  • Chr Location
    4q32.3; chr4:165361194-165498547 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cpe mouse models; 4 with human CPE associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 4 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous or a targeted null mutation display progressive obesity, abnormal blood glucose and lipid regulation, and have reduced fertility. Aberrant prohormone processing and secretion appears to be the cause of these phenotypes. Homozygous KO or homozygosity for an enzymatically inactive mutant leads to depressive-like behavior, in addition to obesity, blood glucose dis-regulation and infertility. KO also leads to hippocampal neurodegeneration after stress and impaired spatial learning and memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    207
  • cDNA Data
    12
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037852 Ensembl Gene Model | MGI Sequence Detail 100513 C57BL/6J ±  kb
    transcript ENSMUST00000048967 Ensembl | MGI Sequence Detail 2117 Not Applicable  
    polypeptide ENSMUSP00000048555 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005804 carboxypeptidase E
      (term hierarchy)
    • EC
      3.4.17.10
    • InterPro Domains
      IPR034232 Carboxypeptidase E, carboxypeptidase domain
      IPR008969 Carboxypeptidase-like, regulatory domain superfamily
      IPR000834 Peptidase M14, carboxypeptidase A
      IPR050753 Peptidase M14 domain-containing protein
      IPR057246 Zinc carboxypeptidases, zinc-binding region 1
      IPR057247 Zinc carboxypeptidases, zinc-binding region 2
    • GlyGen
      Q00493 2 sites, 13 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 15
      Primer pair 7
      Other 3
      Antibodies 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18763, MGD-MRK-2106, MGD-MRK-2107, MGD-MRK-9713, MGI:2142890
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 13
      Phenotypes 77
    • Earliest
      J:10872 Coleman DL, et al., Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J Hered. 1990 Nov-Dec;81(6):424-7
    • Latest
      J:386930 Fan FC, et al., Neurotrophic factor-alpha1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice. Theranostics. 2025;15(6):2279-2292
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory