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Usp15 Gene Detail
Summary
  • Symbol
    Usp15
  • Name
    ubiquitin specific peptidase 15
  • Synonyms
    4921514G19Rik, E430033I05Rik, Gcap18, mKIAA0529
  • Feature Type
    protein coding gene
  • IDs
    MGI:101857
    NCBI Gene: 14479
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:122940911-123032900 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 72.31 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    770 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101857
 protein coding gene Chr10:122940911-123032924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017792
 protein coding gene Chr10:126463297-126551026 (-)
A/J MGP_AJ_G0017767
 protein coding gene Chr10:121403539-121490446 (-)
AKR/J MGP_AKRJ_G0017730
 protein coding gene Chr10:125040917-125127689 (-)
BALB/cJ MGP_BALBcJ_G0017731
 protein coding gene Chr10:121831424-121918695 (-)
C3H/HeJ MGP_C3HHeJ_G0017555
 protein coding gene Chr10:125241917-125329356 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018186
 protein coding gene Chr10:130730358-130817223 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015866
 protein coding gene Chr10:115663320-115752633 (-)
CAST/EiJ MGP_CASTEiJ_G0017115
 protein coding gene Chr10:125647786-125743846 (-)
CBA/J MGP_CBAJ_G0017524
 protein coding gene Chr10:136076268-136163055 (-)
DBA/2J MGP_DBA2J_G0017630
 protein coding gene Chr10:120537427-120624510 (-)
FVB/NJ MGP_FVBNJ_G0017625
 protein coding gene Chr10:119518491-119602450 (-)
LP/J MGP_LPJ_G0017704
 protein coding gene Chr10:126999322-127083406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017653
 protein coding gene Chr10:138563921-138653498 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018226
 protein coding gene Chr10:125088994-125173859 (-)
PWK/PhJ MGP_PWKPhJ_G0016900
 protein coding gene Chr10:120658544-120748711 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016692
 protein coding gene Chr10:123999611-124080248 (-)
WSB/EiJ MGP_WSBEiJ_G0017176
 protein coding gene Chr10:125267246-125351614 (-)



Homology
more
  • Human Ortholog
    USP15, ubiquitin specific peptidase 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP15, ubiquitin specific peptidase 15
  • Synonyms
    UNPH-2, UNPH4
  • Links
    NCBI Gene ID: 9958
    neXtProt AC: NX_Q9Y4E8
    UniProt: Q9Y4E8

  • Chr Location
    12q14.1; chr12:62260338-62417431 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or ENU induced allele exhibit resistance to pathological neuroinflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    16
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020124 Ensembl Gene Model | MGI Sequence Detail 91990 C57BL/6J ±  kb
    transcript ENSMUST00000220377 Ensembl | MGI Sequence Detail 11525 Not Applicable  
    polypeptide ENSMUSP00000151244 Ensembl | MGI Sequence Detail 981 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000017151 ubiquitin carboxyl-terminal hydrolase 15
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR035927 DUSP-like superfamily
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
      IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
      IPR029346 Ubiquitin carboxyl-terminal hydrolase, C-terminal
      IPR029071 Ubiquitin-like domain superfamily
      IPR028135 Ubiquitin-like domain, USP-type
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-18681, MGI:1918171, MGI:2143588
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
    • Latest
      J:339425 Baek JH, et al., Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Exp Mol Med. 2023 Jul;55(7):1520-1530
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory