About   Help   FAQ
Creb3 Gene Detail
Summary
  • Symbol
    Creb3
  • Name
    cAMP responsive element binding protein 3
  • Synonyms
    Luman, LZIP, LZIP-1, LZIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99946
    NCBI Gene: 12913
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43562658-43567061 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99946
 protein coding gene Chr4:43562332-43567061 (+)
129S1/SvImJ ENSMUSG00200004604
 protein coding gene Chr4:39598145-39604512 (+)
A/J ENSMUSG00195003053
 protein coding gene Chr4:40071220-40077582 (+)
AKR/J ENSMUSG00220029606
 protein coding gene Chr4:39758576-39764941 (+)
BALB/cJ ENSMUSG00180022303
 protein coding gene Chr4:39657983-39664345 (+)
C3H/HeJ ENSMUSG00175021268
 protein coding gene Chr4:39802287-39808649 (+)
C57BL/6NJ ENSMUSG00215020802
 protein coding gene Chr4:39582676-39589046 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025942
 protein coding gene Chr4:37652103-37656975 (+)
CAST/EiJ ENSTCUG00005003860
 protein coding gene Chr4:39842758-39849117 (+)
CBA/J ENSMUSG00210006919
 protein coding gene Chr4:39493095-39499457 (+)
DBA/2J ENSMUSG00185005843
 protein coding gene Chr4:39856523-39862885 (+)
FVB/NJ ENSMUSG00205021410
 protein coding gene Chr4:39099813-39106175 (+)
JF1/MsJ ENSUMUG00000019904
 protein coding gene Chr4:40094784-40101151 (+)
LP/J ENSMUSG00230039107
 protein coding gene Chr4:43410522-43416892 (+)
NOD/ShiLtJ ENSMUSG00190005357
 protein coding gene Chr4:39716892-39723257 (+)
NZO/HlLtJ ENSMUSG00225005700
 protein coding gene Chr4:47999687-48006048 (+)
PWK/PhJ ENSLUMG00010006431
 protein coding gene Chr4:39093711-39109081 (+)
SPRET/EiJ ENSMSPG00010020902
 protein coding gene Chr4:40033255-40037857 (+)
WSB/EiJ ENSIUOG00005048630
 protein coding gene Chr4:39469779-39476147 (+)



Homology
more
  • Human Ortholog
    CREB3, cAMP responsive element binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB3, cAMP responsive element binding protein 3
  • Synonyms
    LUMAN, LZIP, sLZIP
  • Links
    NCBI Gene ID: 10488
    UniProt: O43889

  • Chr Location
    9p13.3; chr9:35732296-35738886 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are sub-viable. Heterozygotes are resistant to high-fat diet-induced obesity and hepatic steatosis and show increased energy expenditure and respiratory exchange ratios, altered hepatic lipid profiles, but maintain normal glucose levels on a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    84
  • cDNA Data
    19
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12913 NCBI Gene Model | MGI Sequence Detail 4404 C57BL/6J ±  kb
    transcript NM_013497 RefSeq | MGI Sequence Detail 1559 ZRU/MplStud  
    polypeptide Q61817 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16749, MGI:2140496, MGI:2140584, MGI:2140683
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:17005 Burbelo PD, et al., LZIP-1 and LZIP-2: two novel members of the bZIP family. Gene. 1994 Feb 25;139(2):241-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory