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Tie1 Gene Detail
Summary
  • Symbol
    Tie1
  • Name
    tyrosine kinase with immunoglobulin-like and EGF-like domains 1
  • Synonyms
    D430008P04Rik, TIE, tie-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99906
    NCBI Gene: 21846
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118328388-118347046 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 54.67 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    551 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99906
 protein coding gene Chr4:118328388-118347258 (-)
129S1/SvImJ ENSMUSG00200011646
 protein coding gene Chr4:112227227-112246096 (-)
A/J ENSMUSG00195026692
 protein coding gene Chr4:113478778-113497662 (-)
AKR/J ENSMUSG00220019055
 protein coding gene Chr4:112826599-112845471 (-)
BALB/cJ ENSMUSG00180040331
 protein coding gene Chr4:111545882-111564719 (-)
C3H/HeJ ENSMUSG00175023417
 protein coding gene Chr4:112560052-112578889 (-)
C57BL/6NJ ENSMUSG00215022629
 protein coding gene Chr4:113653389-113672261 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026377
 protein coding gene Chr4:108910600-108931983 (-)
CAST/EiJ ENSTCUG00005043315
 protein coding gene Chr4:112333572-112352470 (-)
CBA/J ENSMUSG00210052012
 protein coding gene Chr4:112173736-112192577 (-)
DBA/2J ENSMUSG00185040608
 protein coding gene Chr4:113704277-113723159 (-)
FVB/NJ ENSMUSG00205028181
 protein coding gene Chr4:111643197-111662033 (-)
JF1/MsJ ENSUMUG00000004954
 protein coding gene Chr4:113621125-113640112 (-)
LP/J ENSMUSG00230043506
 protein coding gene Chr4:117042764-117061634 (-)
NOD/ShiLtJ ENSMUSG00190043571
 protein coding gene Chr4:111541501-111560341 (-)
NZO/HlLtJ ENSMUSG00225010818
 protein coding gene Chr4:122524961-122543835 (-)
PWK/PhJ ENSLUMG00010038371
 protein coding gene Chr4:111004705-111023587 (-)
SPRET/EiJ ENSMSPG00010037675
 protein coding gene Chr4:113093593-113112961 (-)
WSB/EiJ ENSIUOG00005043473
 protein coding gene Chr4:111859456-111878342 (-)



Homology
more
  • Human Ortholog
    TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
  • Synonyms
    JTK14, LMPHM11, TIE
  • Links
    NCBI Gene ID: 7075
    UniProt: P35590

  • Chr Location
    1p34.2; chr1:43300971-43323108 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TIE1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 7 alleles in 10 genetic backgrounds
    19 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic or neonatal lethality, hemorrhages, edema, increased vascular branching, and abnormal vascular endothelial cell development. Mice homozygous for a hypomorphic allele exhibit dilated and disorganized lymphatic vessel, edema, and hemorrhage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    145
  • cDNA Data
    43
  • Literature Summary
    88
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21846 NCBI Gene Model | MGI Sequence Detail 18659 C57BL/6J ±  kb
    transcript NM_011587 RefSeq | MGI Sequence Detail 3883 ZRU/MplStud  
    polypeptide Q06806 UniProt | EBI | MGI Sequence Detail 1134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 1
      cDNA 44
      Primer pair 16
      Other 8
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16703, MGI:2443090
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 88
      Gene Ontology 17
      Phenotypes 45
    • Earliest
      J:193673 Korhonen J, et al., Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization. Blood. 1992 Nov 15;80(10):2548-55
    • Latest
      J:385781 Tang T, et al., Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons. J Neurosci. 2026 Apr 8;46(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory