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Rcvrn Gene Detail
Summary
  • Symbol
    Rcvrn
  • Name
    recoverin
  • Synonyms
    cancer associated retinopathy protein, guanylate cyclase activator, S-modulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97883
    NCBI Gene: 19674
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:67586152-67594159 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 41.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    427 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97883
 protein coding gene Chr11:67586152-67594181 (+)
129S1/SvImJ ENSMUSG00200047574
 protein coding gene Chr11:64535206-64543240 (+)
A/J ENSMUSG00195037430
 protein coding gene Chr11:64554593-64562623 (+)
AKR/J ENSMUSG00220040535
 protein coding gene Chr11:64670857-64678893 (+)
BALB/cJ ENSMUSG00180053423
 protein coding gene Chr11:64622650-64630676 (+)
C3H/HeJ ENSMUSG00175042938
 protein coding gene Chr11:64573059-64581088 (+)
C57BL/6NJ ENSMUSG00215050350
 protein coding gene Chr11:64354686-64362689 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016529
 protein coding gene Chr11:62416254-62424350 (+)
CAST/EiJ ENSTCUG00005047763
 protein coding gene Chr11:64101488-64109548 (+)
CBA/J ENSMUSG00210050819
 protein coding gene Chr11:64427150-64435173 (+)
DBA/2J ENSMUSG00185053921
 protein coding gene Chr11:64621384-64629409 (+)
FVB/NJ ENSMUSG00205022755
 protein coding gene Chr11:64520578-64528622 (+)
JF1/MsJ ENSUMUG00000027267
 protein coding gene Chr11:65020802-65028852 (+)
LP/J ENSMUSG00230053123
 protein coding gene Chr11:65745656-65753687 (+)
NOD/ShiLtJ ENSMUSG00190053958
 protein coding gene Chr11:64654074-64662116 (+)
NZO/HlLtJ ENSMUSG00225043659
 protein coding gene Chr11:67925508-67933562 (+)
PWK/PhJ ENSLUMG00010053277
 protein coding gene Chr11:64539956-64547992 (+)
SPRET/EiJ ENSMSPG00010043369
 protein coding gene Chr11:65277273-65285110 (+)
WSB/EiJ ENSIUOG00005047976
 protein coding gene Chr11:64557669-64565704 (+)



Homology
more
  • Human Ortholog
    RCVRN, recoverin
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RCVRN, recoverin
  • Synonyms
    RCV1
  • Links
    NCBI Gene ID: 5957
    UniProt: P35243

  • Chr Location
    17p13.1; chr17:9896320-9905271 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit faster flash response recovery in dark-adapted rods, decreased sensitivity of rods to steps of light and altered kinetics of sodium/calcium-potassium exchange in rods.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    663
  • Tissues
    18
  • cDNA Data
    6
  • Literature Summary
    80
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020907 Ensembl Gene Model | MGI Sequence Detail 8008 C57BL/6J ±  kb
    transcript ENSMUST00000021290 Ensembl | MGI Sequence Detail 1040 Not Applicable  
    polypeptide ENSMUSP00000021290 Ensembl | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 1
      Other 1
      Antibodies 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13806
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 80
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:377759 Liu S, et al., Foxn3 is required to suppress aberrant ciliogenesis in nonphotoreceptor retinal neurons. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2500871122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory