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Krt19 Gene Detail
Summary
  • Symbol
    Krt19
  • Name
    keratin 19
  • Synonyms
    cytokeratin 19, cytokeratin-19, cytokeratin19, EndoC, K19, Krt-1.19, Krt1-19, MGC:25344
  • Feature Type
    protein coding gene
  • IDs
    MGI:96693
    NCBI Gene: 16669
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100031636-100036752 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.42 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96693
 protein coding gene Chr11:100031636-100039491 (-)
129S1/SvImJ ENSMUSG00200050771
 protein coding gene Chr11:97302845-97308155 (-)
A/J ENSMUSG00195049471
 protein coding gene Chr11:96983935-96989259 (-)
AKR/J ENSMUSG00220050879
 protein coding gene Chr11:97236792-97242106 (-)
BALB/cJ ENSMUSG00180051828
 protein coding gene Chr11:97365309-97370598 (-)
C3H/HeJ ENSMUSG00175039618
 protein coding gene Chr11:97276405-97281715 (-)
C57BL/6NJ ENSMUSG00215052203
 protein coding gene Chr11:96850591-96855901 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017161
 protein coding gene Chr11:96001166-96009090 (-)
CAST/EiJ ENSTCUG00005046681
 protein coding gene Chr11:96776956-96782354 (-)
CBA/J ENSMUSG00210052393
 protein coding gene Chr11:96998669-97003958 (-)
DBA/2J ENSMUSG00185042121
 protein coding gene Chr11:97326283-97331593 (-)
FVB/NJ ENSMUSG00205039246
 protein coding gene Chr11:97181475-97186785 (-)
JF1/MsJ ENSUMUG00000017549
 protein coding gene Chr11:97578579-97584039 (-)
LP/J ENSMUSG00230048855
 protein coding gene Chr11:98379029-98384339 (-)
NOD/ShiLtJ ENSMUSG00190043612
 protein coding gene Chr11:97361076-97366390 (-)
NZO/HlLtJ ENSMUSG00225049777
 protein coding gene Chr11:100415508-100420797 (-)
PWK/PhJ ENSLUMG00010040704
 protein coding gene Chr11:97135200-97140617 (-)
SPRET/EiJ ENSMSPG00010044139
 protein coding gene Chr11:97625904-97631176 (-)
WSB/EiJ ENSIUOG00005049593
 protein coding gene Chr11:97125493-97130787 (-)



Homology
more
  • Human Ortholog
    KRT19, keratin 19
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT19, keratin 19
  • Synonyms
    CK19, K19, K1CS
  • Links
    NCBI Gene ID: 3880
    UniProt: P08727

  • Chr Location
    17q21.2; chr17:41523613-41528308 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    51 phenotypes from multigenic genotypes
    2 images
    139 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele are viable. Mice homozygous for a reporter allele show partial and strain-dependent preweaning lethality but no anatomical or behavioral defects. Mice that are either homozygous or heterozygous for a targeted insertion into intron 6 exhibit sperm tail defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1212
  • Tissues
    203
  • cDNA Data
    297
  • Literature Summary
    164
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16669 NCBI Gene Model | MGI Sequence Detail 5117 C57BL/6J ±  kb
transcript NM_008471 RefSeq | MGI Sequence Detail 1396 ZRU/MplStud  
polypeptide P19001 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 320
    Genomic 10
    cDNA 297
    Primer pair 13
    Antibodies 19

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11633, MGD-MRK-11648, MGI:2144260
References
more
  • Summaries
    All 334
    Developmental Gene Expression 164
    Gene Ontology 12
    Phenotypes 139
  • Earliest
    J:10112 Ichinose Y, et al., Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19. Gene. 1989 Aug 15;80(2):315-23
  • Latest
    J:390258 Dalal V, et al., Transcription factor 21 deletion from podocyte precursors as a model for congenital nephrotic syndrome. Am J Physiol Renal Physiol. 2026 Jun 1;330(6):F746-F760
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory