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Grin2c Gene Detail
Summary
  • Symbol
    Grin2c
  • Name
    glutamate receptor, ionotropic, NMDA2C (epsilon 3)
  • Synonyms
    GluRepsilon3, NMDAR2C, NR2C
  • Feature Type
    protein coding gene
  • IDs
    MGI:95822
    NCBI Gene: 14813
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115139995-115158069 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.80 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95822
 protein coding gene Chr11:115139995-115158123 (-)
129S1/SvImJ ENSMUSG00200047312
 protein coding gene Chr11:112510690-112528754 (-)
A/J ENSMUSG00195025673
 protein coding gene Chr11:112212549-112230557 (-)
AKR/J ENSMUSG00220026388
 protein coding gene Chr11:112313531-112331541 (-)
BALB/cJ ENSMUSG00180046737
 protein coding gene Chr11:112511323-112529387 (-)
C3H/HeJ ENSMUSG00175044722
 protein coding gene Chr11:112464445-112482451 (-)
C57BL/6NJ ENSMUSG00215046109
 protein coding gene Chr11:111999837-112017919 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017392
 protein coding gene Chr11:111092563-111110773 (-)
CAST/EiJ ENSTCUG00005039921
 protein coding gene Chr11:111869085-111887186 (-)
CBA/J ENSMUSG00210047248
 protein coding gene Chr11:112184446-112202452 (-)
DBA/2J ENSMUSG00185026456
 protein coding gene Chr11:112503057-112521135 (-)
FVB/NJ ENSMUSG00205028733
 protein coding gene Chr11:112303311-112321402 (-)
JF1/MsJ ENSUMUG00000018803
 protein coding gene Chr11:112773256-112791424 (-)
LP/J ENSMUSG00230050130
 protein coding gene Chr11:113557851-113575857 (-)
NOD/ShiLtJ ENSMUSG00190029085
 protein coding gene Chr11:112535215-112553277 (-)
NZO/HlLtJ ENSMUSG00225052447
 protein coding gene Chr11:115613340-115631402 (-)
PWK/PhJ ENSLUMG00010015547
 protein coding gene Chr11:112286836-112304985 (-)
SPRET/EiJ ENSMSPG00010042818
 protein coding gene Chr11:112798411-112815745 (-)
WSB/EiJ ENSIUOG00005041630
 protein coding gene Chr11:112273234-112291308 (-)



Homology
more
  • Human Ortholog
    GRIN2C, glutamate ionotropic receptor NMDA type subunit 2C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN2C, glutamate ionotropic receptor NMDA type subunit 2C
  • Synonyms
    GluN2C, NMDAR2C, NR2C
  • Links
    NCBI Gene ID: 2905
    UniProt: Q14957

  • Chr Location
    17q25.1; chr17:74842022-74861767 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 6 alleles in 5 genetic backgrounds
    17 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit deficits in motor coordination and reduced granule cell responses to N-methy-D-aspartate in brain slices.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    91
  • cDNA Data
    21
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020734 Ensembl Gene Model | MGI Sequence Detail 18075 C57BL/6J ±  kb
    transcript ENSMUST00000003351 Ensembl | MGI Sequence Detail 4279 Not Applicable  
    polypeptide ENSMUSP00000003351 Ensembl | MGI Sequence Detail 1239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008248 glutamate receptor ionotropic, NMDA 2C
      (term hierarchy)
    • InterPro Domains
      IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q01098 8 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 7
      cDNA 21
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10260
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 19
      Gene Ontology 24
      Phenotypes 53
    • Earliest
      J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
    • Latest
      J:390313 Olah VJ, et al., Bidirectional control of vesicular GABA release, LTP, and amotivation by GluN2D-selective allosteric modulators and ketamine. Cell Rep. 2026 Jul 24;45(8):117707
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory