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Gnai2 Gene Detail
Summary
  • Symbol
    Gnai2
  • Name
    G protein subunit alpha i2
  • Synonyms
    Galphai2, Gia, Gnai-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95772
    NCBI Gene: 14678
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107491324-107512542 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.43 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    27
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95772
 protein coding gene Chr9:107491324-107512566 (-)
129S1/SvImJ ENSMUSG00200042358
 protein coding gene Chr9:104707903-104708041 (-)
129S1/SvImJ ENSMUSGG00200054870
 protein coding gene Chr9:104688986-104692930 (-)
A/J ENSMUSG00195036953
 protein coding gene Chr9:103926674-103926812 (-)
A/J ENSMUSGG00195055479
 protein coding gene Chr9:103907756-103911701 (-)
AKR/J ENSMUSGG00220054414
 protein coding gene Chr9:104297643-104301588 (-)
AKR/J ENSMUSG00220024140
 protein coding gene Chr9:104316563-104316701 (-)
BALB/cJ ENSMUSGG00180055141
 protein coding gene Chr9:104224212-104228156 (-)
BALB/cJ ENSMUSG00180032594
 protein coding gene Chr9:104243132-104243270 (-)
C3H/HeJ ENSMUSGG00175054698
 protein coding gene Chr9:104566520-104570464 (-)
C3H/HeJ ENSMUSG00175042858
 protein coding gene Chr9:104585437-104585575 (-)
C57BL/6NJ ENSMUSGG00215055254
 protein coding gene Chr9:104544055-104548017 (-)
C57BL/6NJ ENSMUSG00215028858
 protein coding gene Chr9:104562649-104562787 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032656
 protein coding gene Chr9:102940535-102962266 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210033744
 protein coding gene Chr9:104432797-104432935 (-)
CBA/J ENSMUSGG00210054686
 protein coding gene Chr9:104414198-104418157 (-)
DBA/2J ENSMUSGG00185057419
 protein coding gene Chr9:104579023-104582984 (-)
DBA/2J ENSMUSG00185036784
 protein coding gene Chr9:104597620-104597758 (-)
FVB/NJ ENSMUSG00205047408
 protein coding gene Chr9:104596134-104596272 (-)
FVB/NJ ENSMUSGG00205054594
 protein coding gene Chr9:104577214-104581159 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055807
 protein coding gene Chr9:104717920-104721864 (-)
LP/J ENSMUSG00230050038
 protein coding gene Chr9:104736837-104736975 (-)
NOD/ShiLtJ ENSMUSGG00190054592
 protein coding gene Chr9:104214416-104218360 (-)
NOD/ShiLtJ ENSMUSG00190048021
 protein coding gene Chr9:104233335-104233473 (-)
NZO/HlLtJ ENSMUSGG00225055579
 protein coding gene Chr9:104952037-104955981 (-)
NZO/HlLtJ ENSMUSG00225023728
 protein coding gene Chr9:104970954-104971092 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010040125
 protein coding gene Chr9:106190825-106210361 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GNAI2, G protein subunit alpha i2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAI2, G protein subunit alpha i2
  • Synonyms
    GIP, GNAI2B, HG1C, H_LUCA15.1, H_LUCA16.1
  • Links
    NCBI Gene ID: 2771
    UniProt: P04899

  • Chr Location
    3p21.31; chr3:50226292-50259362 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gnai2 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 5 alleles in 12 genetic backgrounds
    17 phenotypes from multigenic genotypes
    2 images
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit growth retardation, lethal ulcerative colitis, colon adenocarcinomas, granulocytosis, altered thymocyte maturation and function and enhanced production of pro-inflammatory cytokines, and may show alterations in leukocyte physiology and susceptibility to parasitic infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    899
  • Tissues
    160
  • cDNA Data
    471
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14678 NCBI Gene Model | MGI Sequence Detail 21219 C57BL/6J ±  kb
    transcript NM_008138 RefSeq | MGI Sequence Detail 2227 ZRU/MplStud  
    polypeptide P08752 UniProt | EBI | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008086 guanine nucleotide-binding protein G(i) subunit alpha-2
      (term hierarchy)
    • EC
      3.6.5.-
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein, alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P08752 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 487
      Genomic 3
      cDNA 474
      Primer pair 5
      Other 5
      Antibodies 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10075, MGD-MRK-10181, MGD-MRK-10184, MGI:2143377
    References
    more
    • Summaries
      All 253
      Developmental Gene Expression 33
      Diseases 3
      Gene Ontology 17
      Phenotypes 127
    • Earliest
      J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
    • Latest
      J:378730 Ham H, et al., Germline mutations in a G protein identify signaling cross-talk in T cells. Science. 2024 Sep 20;385(6715):eadd8947
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory