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Fgf5 Gene Detail
Summary
  • Symbol
    Fgf5
  • Name
    fibroblast growth factor 5
  • Synonyms
    Fgf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95519
    NCBI Gene: 14176
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:98402108-98424892 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.77 cM, cytoband E1-F
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    724 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95519
 protein coding gene Chr5:98402043-98424892 (+)
129S1/SvImJ ENSMUSG00200005807
 protein coding gene Chr5:92125354-92148194 (+)
A/J ENSMUSG00195034116
 protein coding gene Chr5:91684076-91707115 (+)
AKR/J ENSMUSG00220037011
 protein coding gene Chr5:91153800-91176663 (+)
BALB/cJ ENSMUSG00180024799
 protein coding gene Chr5:91840505-91863362 (+)
C3H/HeJ ENSMUSG00175031294
 protein coding gene Chr5:93938854-93961707 (+)
C57BL/6NJ ENSMUSG00215009940
 protein coding gene Chr5:91785179-91808028 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027439
 protein coding gene Chr5:91210539-91232964 (+)
CAST/EiJ ENSTCUG00005022768
 protein coding gene Chr5:91181431-91204306 (+)
CBA/J ENSMUSG00210033005
 protein coding gene Chr5:92697952-92720803 (+)
DBA/2J ENSMUSG00185033828
 protein coding gene Chr5:95613926-95636789 (+)
FVB/NJ ENSMUSG00205021264
 protein coding gene Chr5:91602535-91625393 (+)
JF1/MsJ ENSUMUG00000042174
 protein coding gene Chr5:98573229-98596025 (+)
LP/J ENSMUSG00230025344
 protein coding gene Chr5:99678317-99701159 (+)
NOD/ShiLtJ ENSMUSG00190021795
 protein coding gene Chr5:91610377-91633416 (+)
NZO/HlLtJ ENSMUSG00225012714
 protein coding gene Chr5:107429767-107452636 (+)
PWK/PhJ ENSLUMG00010024934
 protein coding gene Chr5:90699955-90722802 (+)
SPRET/EiJ ENSMSPG00010025125
 protein coding gene Chr5:93579985-93601762 (+)
WSB/EiJ ENSIUOG00005029804
 protein coding gene Chr5:94323007-94345869 (+)



Homology
more
  • Human Ortholog
    FGF5, fibroblast growth factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF5, fibroblast growth factor 5
  • Synonyms
    HBGF-5, Smag-82, TCMGLY
  • Links
    NCBI Gene ID: 2250
    UniProt: P12034

  • Chr Location
    4q21.21; chr4:80266588-80336680 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FGF5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in significantly longer pelage hair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1079
  • Tissues
    337
  • cDNA Data
    21
  • Literature Summary
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14176 NCBI Gene Model | MGI Sequence Detail 22785 C57BL/6J ±  kb
    transcript NM_010203 RefSeq | MGI Sequence Detail 2439 ZRU/MplStud  
    polypeptide P15656 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 5
      cDNA 24
      Primer pair 16
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10212, MGD-MRK-9764, MGD-MRK-9770
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 64
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:379337 Fons JM, et al., Analysis of Eya1 and Tbx1 mutants highlights interactions between the muscle and developing cartilage during external ear formation. Development. 2026 Feb 1;153(3):dev204784
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory