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Adamts15 Gene Detail
Summary
  • Symbol
    Adamts15
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449569
    NCBI Gene: 235130
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:30810451-30833748 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 16.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    681 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449569
 protein coding gene Chr9:30810451-30833853 (-)
129S1/SvImJ ENSMUSG00200007695
 protein coding gene Chr9:27803581-27826879 (-)
A/J ENSMUSG00195005920
 protein coding gene Chr9:27615525-27638823 (-)
AKR/J ENSMUSG00220010338
 protein coding gene Chr9:27650783-27674082 (-)
BALB/cJ ENSMUSG00180006540
 protein coding gene Chr9:27743968-27767269 (-)
C3H/HeJ ENSMUSG00175019009
 protein coding gene Chr9:27724547-27747846 (-)
C57BL/6NJ ENSMUSG00215007125
 protein coding gene Chr9:27705925-27729230 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031933
 protein coding gene Chr9:26685183-26708747 (-)
CAST/EiJ ENSTCUG00005018787
 protein coding gene Chr9:27704188-27727669 (-)
CBA/J ENSMUSG00210022048
 protein coding gene Chr9:27756550-27779911 (-)
DBA/2J ENSMUSG00185002122
 protein coding gene Chr9:27802364-27825661 (-)
FVB/NJ ENSMUSG00205004266
 protein coding gene Chr9:28104681-28127982 (-)
JF1/MsJ ENSUMUG00000011090
 protein coding gene Chr9:27974292-27997632 (-)
LP/J ENSMUSG00230004520
 protein coding gene Chr9:28239425-28262766 (-)
NOD/ShiLtJ ENSMUSG00190005911
 protein coding gene Chr9:27841850-27865143 (-)
NZO/HlLtJ ENSMUSG00225014629
 protein coding gene Chr9:28215773-28239108 (-)
PWK/PhJ ENSLUMG00010009067
 protein coding gene Chr9:27836088-27859475 (-)
SPRET/EiJ ENSMSPG00010001986
 protein coding gene Chr9:28193304-28216858 (-)
WSB/EiJ ENSIUOG00005015427
 protein coding gene Chr9:27276823-27300305 (-)



Homology
more
  • Human Ortholog
    ADAMTS15, ADAM metallopeptidase with thrombospondin type 1 motif 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS15, ADAM metallopeptidase with thrombospondin type 1 motif 15
  • Synonyms
    DA12
  • Links
    NCBI Gene ID: 170689
    UniProt: Q8TE58

  • Chr Location
    11q24.3; chr11:130448645-130476645 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADAMTS15 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele are fertile and exhibit normal testis gross appearance, normal testis and epididymis histology and germ cell number, and normal sperm morphology and motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    95
  • cDNA Data
    45
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033453 Ensembl Gene Model | MGI Sequence Detail 23298 C57BL/6J ±  kb
    transcript ENSMUST00000065112 Ensembl | MGI Sequence Detail 5928 Not Applicable  
    polypeptide ENSMUSP00000067022 Ensembl | MGI Sequence Detail 950 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 45
      Primer pair 4
      Other 1
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 14
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:139177 Hoffman BG, et al., Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
    • Latest
      J:388025 Opoku G, et al., ADAMTS1 Is Required for Ventral Abdominal Wall Closure. J Histochem Cytochem. 2026 Apr 28;:221554261438169
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory