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H4c1 Gene Detail
Summary
  • Symbol
    H4c1
  • Name
    H4 clustered histone 1
  • Synonyms
    Hist1h4a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448419
    NCBI Gene: 326619
  • Member of
    Hist1 cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23944778-23945232 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.91 cM, cytoband A2-A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448419
 protein coding gene Chr13:23944675-23945232 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0018337
 protein coding gene Chr13:19587539-19588079 (-)
CAST/EiJ ENSTCUG00005010261
 protein coding gene Chr13:20722367-20722907 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000010602
 protein coding gene Chr13:20990621-20991161 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010029080
 protein coding gene Chr13:19881547-19882087 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005032313
 protein coding gene Chr13:19846324-19846862 (-)



Homology
more
  • Human Ortholog
    H4C1, H4 clustered histone 1
  • Vertebrate Orthologs
    31
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H4C1, H4 clustered histone 1
  • Synonyms
    H4FA, HIST1H4A
  • Links
    NCBI Gene ID: 8359
    UniProt: P62805

  • Chr Location
    6p22.2; chr6:26021649-26022847 (+)  GRCh38
  • Human Ortholog
    H4C11, H4 clustered histone 11
  • Synonyms
    dJ160A22.2, H4/e, H4F2iv, H4FE, HIST1H4J, TEBIVANED2, TEVANED2
  • Links
    NCBI Gene ID: 8363
    UniProt: P62805

  • Chr Location
    6p22.1; chr6:27824092-27824480 (+)  GRCh38
  • Human Ortholog
    H4C12, H4 clustered histone 12
  • Synonyms
    dJ160A22.1, H4/d, H4F2iii, H4FD, HIST1H4K
  • Links
    NCBI Gene ID: 8362
    UniProt: P62805

  • Chr Location
    6p22.1; chr6:27830918-27831560 (-)  GRCh38
  • Human Ortholog
    H4C13, H4 clustered histone 13
  • Synonyms
    H4FK, H4.k, H4/k, HIST1H4L
  • Links
    NCBI Gene ID: 8368
    UniProt: P62805

  • Chr Location
    6p22.1; chr6:27873148-27873534 (-)  GRCh38
  • Human Ortholog
    H4C14, H4 clustered histone 14
  • Synonyms
    FO108, H4, H4F2, H4FN, H4/n, HIST2H4, HIST2H4A
  • Links
    NCBI Gene ID: 8370
    UniProt: P62805

  • Chr Location
    1q21.2; chr1:149832657-149839767 (+)  GRCh38
  • Human Ortholog
    H4C15, H4 clustered histone 15
  • Synonyms
    H4/o, HIST2H4B
  • Links
    NCBI Gene ID: 554313
    UniProt: P62805

  • Chr Location
    1q21.2; chr1:149844488-149861240 (-)  GRCh38
  • Human Ortholog
    H4C16, H4 histone 16
  • Synonyms
    H4-16, H4/p, HIST4H4
  • Links
    NCBI Gene ID: 121504
    UniProt: P62805

  • Chr Location
    12p12.3; chr12:14767999-14771131 (-)  GRCh38
  • Human Ortholog
    H4C2, H4 clustered histone 2
  • Synonyms
    H4FI, H4/I, HIST1H4B
  • Links
    NCBI Gene ID: 8366
    UniProt: P62805

  • Chr Location
    6p22.2; chr6:26025802-26027283 (-)  GRCh38
  • Human Ortholog
    H4C3, H4 clustered histone 3
  • Synonyms
    dJ221C16.1, H4FG, H4/g, HIST1H4C, TEBIVANED1, TEVANED1
  • Links
    NCBI Gene ID: 8364
    UniProt: P62805

  • Chr Location
    6p22.2; chr6:26103933-26104337 (+)  GRCh38
  • Human Ortholog
    H4C4, H4 clustered histone 4
  • Synonyms
    dJ221C16.9, H4/b, H4FB, HIST1H4D
  • Links
    NCBI Gene ID: 8360
    UniProt: P62805

  • Chr Location
    6p22.2; chr6:26188710-26189112 (-)  GRCh38
  • Human Ortholog
    H4C5, H4 clustered histone 5
  • Synonyms
    H4FJ, H4/j, HIST1H4E, TEBIVANED3, TEVANED3
  • Links
    NCBI Gene ID: 8367
    UniProt: P62805

  • Chr Location
    6p22.2; chr6:26204610-26205021 (+)  GRCh38
  • Human Ortholog
    H4C6, H4 clustered histone 6
  • Synonyms
    H4, H4/c, H4FC, HIST1H4F
  • Links
    NCBI Gene ID: 8361
    UniProt: P62805

  • Chr Location
    6p22.2; chr6:26240393-26240793 (+)  GRCh38
  • Human Ortholog
    H4C8, H4 clustered histone 8
  • Synonyms
    H4FH, H4/h, HIST1H4H
  • Links
    NCBI Gene ID: 8365
    UniProt: P62805

  • Chr Location
    6p22.2; chr6:26277609-26285638 (-)  GRCh38
  • Human Ortholog
    H4C9, H4 clustered histone 9
  • Synonyms
    H4FM, H4/m, H4M, HIST1H4I, TEBIVANED4, TEVANED4
  • Links
    NCBI Gene ID: 8294
    UniProt: P62805

  • Chr Location
    6p22.1; chr6:27139282-27140640 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    629
  • Tissues
    24
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 326619 NCBI Gene Model | MGI Sequence Detail 455 C57BL/6J ±  kb
    transcript NM_178192 RefSeq | MGI Sequence Detail 455 C57BL/6  
    polypeptide P62806 UniProt | EBI | MGI Sequence Detail 103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 6
      Genomic 1
      cDNA 4
      Primer pair 1
      Antibodies 1
    Other
    Accession IDs
    less
    MGI:6324963
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:320332 Kujirai T, et al., Transcription through the nucleosome. Curr Opin Struct Biol. 2020 Apr;61:42-49
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory