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Sequence Detail
P62806 A4FUP8 Q6PDS7 A4QMY0 P02305 P02304 Q5T006 Q811M0 Q2M2Q5 A0AUM5 Q9D6Q8 Q0VDL9 Q9D0C9 (UniProt | EBI) Last sequence update: 2007-01-23
Last annotation update: 2024-05-29
from provider
RecName: Full=Histone H4;
Polypeptide 103 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene H4c1 H4 clustered histone 1 4 102 16 4
Gene H4c11 H4 clustered histone 11 4 101 16 2
Gene H4c12 H4 clustered histone 12 4 101 16 2
Gene H4c14 H4 clustered histone 14 8 104 16 4
Gene H4c16 H4 histone 16 4 101 17 5
Gene H4c17 H4 clustered histone 17 4 101 16 2
Gene H4c2 H4 clustered histone 2 4 101 16 3
Gene H4c3 H4 clustered histone 3 4 107 16 4
Gene H4c4 H4 clustered histone 4 4 102 16 2
Gene H4c6 H4 clustered histone 6 4 101 16 3
Gene H4c8 H4 clustered histone 8 4 102 16 2
Gene H4c9 H4 clustered histone 9 4 101 16 5
Sequence references in MGI J:20236 Meier VS, et al., Nucleotide sequence of two mouse histone H4 genes. Nucleic Acids Res. 1989 Jan 25;17(2):795
J:33128 Seiler-Tuyns A, et al., Structure and expression in L-cells of a cloned H4 histone gene of the mouse. J Mol Biol. 1981 Oct 5;151(4):607-25
J:34962 Wang ZF, et al., Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb. Genome Res. 1996 Aug;6(8):688-701
J:80094 Marzluff WF, et al., The human and mouse replication-dependent histone genes. Genomics. 2002 Nov;80(5):487-98
J:90491 Schotta G, et al., A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109626 Ancelin K, et al., Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol. 2006 Jun;8(6):623-30
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:211428 Southall SM, et al., A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res. 2014 Jan;42(1):661-71
J:243518 Goudarzi A, et al., Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol Cell. 2016 Apr 21;62(2):169-80
J:253015 Xie Z, et al., Metabolic Regulation of Gene Expression by Histone Lysine beta-Hydroxybutyrylation. Mol Cell. 2016 Apr 21;62(2):194-206
J:287408 Zhang D, et al., Metabolic regulation of gene expression by histone lactylation. Nature. 2019 Oct;574(7779):575-580
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319948 Kelly RDW, et al., Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. Sci Rep. 2018 Oct 2;8(1):14690

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory