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Fitm2 Gene Detail
Summary
  • Symbol
    Fitm2
  • Name
    fat storage-inducing transmembrane protein 2
  • Synonyms
    D930001I22Rik, Fit2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444508
    NCBI Gene: 228859
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163310623-163314549 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444508
 protein coding gene Chr2:163308299-163314549 (-)
129S1/SvImJ ENSMUSG00200016445
 protein coding gene Chr2:160209266-160215516 (-)
A/J ENSMUSG00195015751
 protein coding gene Chr2:160550141-160556391 (-)
AKR/J ENSMUSG00220013692
 protein coding gene Chr2:159871059-159877309 (-)
BALB/cJ ENSMUSG00180044718
 protein coding gene Chr2:160003875-160010125 (-)
C3H/HeJ ENSMUSG00175050486
 protein coding gene Chr2:160753629-160759879 (-)
C57BL/6NJ ENSMUSG00215036343
 protein coding gene Chr2:160178134-160184384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024616
 protein coding gene Chr2:155308848-155315153 (-)
CAST/EiJ ENSTCUG00005042961
 protein coding gene Chr2:159110021-159116324 (-)
CBA/J ENSMUSG00210015397
 protein coding gene Chr2:160684666-160690916 (-)
DBA/2J ENSMUSG00185047515
 protein coding gene Chr2:160414386-160420636 (-)
FVB/NJ ENSMUSG00205033612
 protein coding gene Chr2:159443690-159449940 (-)
JF1/MsJ ENSUMUG00000007473
 protein coding gene Chr2:160059561-160065864 (-)
LP/J ENSMUSG00230043624
 protein coding gene Chr2:161978911-161985161 (-)
NOD/ShiLtJ ENSMUSG00190041492
 protein coding gene Chr2:160054337-160060587 (-)
NZO/HlLtJ ENSMUSG00225050184
 protein coding gene Chr2:169971084-169977334 (-)
PWK/PhJ ENSLUMG00010043645
 protein coding gene Chr2:159965852-159972163 (-)
SPRET/EiJ ENSMSPG00010027034
 protein coding gene Chr2:162742554-162746150 (-)
WSB/EiJ ENSIUOG00005039431
 protein coding gene Chr2:159807628-159814141 (-)



Homology
more
  • Human Ortholog
    FITM2, fat storage inducing transmembrane protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FITM2, fat storage inducing transmembrane protein 2
  • Synonyms
    C20orf142, dJ881L22.2, Fit2, SIDDIS
  • Links
    NCBI Gene ID: 128486
    UniProt: Q8N6M3

  • Chr Location
    20q13.12; chr20:44302840-44311202 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FITM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    5 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal, while heterozygous KO increases survival after and reduces susceptibility to pressure overload-induced heart failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    649
  • Tissues
    45
  • cDNA Data
    68
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228859 NCBI Gene Model | MGI Sequence Detail 3927 C57BL/6J ±  kb
    transcript NM_173397 RefSeq | MGI Sequence Detail 1643 C57BL/6  
    polypeptide P59266 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 68

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138930
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:373882 Wang H, et al., FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver. Mol Metab. 2024 Oct 18;90:102048
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory