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Mcat Gene Detail
Summary
  • Symbol
    Mcat
  • Name
    malonyl CoA:ACP acyltransferase (mitochondrial)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388651
    NCBI Gene: 223722
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:83430998-83439936 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388651
 protein coding gene Chr15:83430998-83447988 (-)
129S1/SvImJ ENSMUSG00200053409
 protein coding gene Chr15:80557067-80566006 (-)
A/J ENSMUSG00195043292
 protein coding gene Chr15:80482799-80491739 (-)
AKR/J ENSMUSG00220052367
 protein coding gene Chr15:80526479-80535416 (-)
BALB/cJ ENSMUSG00180044538
 protein coding gene Chr15:80359706-80368644 (-)
C3H/HeJ ENSMUSG00175050580
 protein coding gene Chr15:80670638-80679576 (-)
C57BL/6NJ ENSMUSG00215052371
 protein coding gene Chr15:80448629-80457569 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020101
 protein coding gene Chr15:77547851-77556996 (-)
CAST/EiJ ENSTCUG00005038981
 protein coding gene Chr15:79950733-79959688 (-)
CBA/J ENSMUSG00210047839
 protein coding gene Chr15:80445632-80454572 (-)
DBA/2J ENSMUSG00185046649
 protein coding gene Chr15:80479696-80488635 (-)
FVB/NJ ENSMUSG00205044116
 protein coding gene Chr15:80227595-80236535 (-)
JF1/MsJ ENSUMUG00000019893
 protein coding gene Chr15:80009397-80018574 (-)
LP/J ENSMUSG00230041551
 protein coding gene Chr15:83797393-83806332 (-)
NOD/ShiLtJ ENSMUSG00190029387
 protein coding gene Chr15:80462755-80471691 (-)
NZO/HlLtJ ENSMUSG00225048357
 protein coding gene Chr15:84130494-84139431 (-)
PWK/PhJ ENSLUMG00010040026
 protein coding gene Chr15:80213056-80222212 (-)
SPRET/EiJ ENSMSPG00010049666
 protein coding gene Chr15:81873157-81881743 (-)
WSB/EiJ ENSIUOG00005039203
 protein coding gene Chr15:80545994-80554938 (-)



Homology
more
  • Human Ortholog
    MCAT, malonyl-CoA-acyl carrier protein transacylase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCAT, malonyl-CoA-acyl carrier protein transacylase
  • Synonyms
    fabD, FASN2C, MCT, MCT1, MT, NET62, OPA15
  • Links
    NCBI Gene ID: 27349
    UniProt: Q8IVS2

  • Chr Location
    22q13.2; chr22:43132206-43143398 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MCAT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 1 allele in 2 genetic backgrounds
    3 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated ubiquitously consume more food, fail to gain weight, are less physically active, and suffer from loss of white adipose tissue, reduced muscle strength, kyphosis, alopecia, hypothermia and shortened lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    30
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223722 NCBI Gene Model | MGI Sequence Detail 8939 C57BL/6J ±  kb
    transcript NM_001416006 RefSeq | MGI Sequence Detail 1995 C57BL/6  
    polypeptide Q8R3F5 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010231 malonyl-CoA-acyl carrier protein transacylase, mitochondrial
      (term hierarchy)
    • EC
      2.3.1.39
    • InterPro Domains
      IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
      IPR014043 Acyl transferase domain
      IPR001227 Acyl transferase domain superfamily
      IPR016036 Malonyl-CoA ACP transacylase, ACP-binding
      IPR052760 Mitochondrial malonyltransferase
    • GlyGen
      Q8R3F5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 2
      cDNA 30

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145961
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 11
      Phenotypes 28
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory