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Lzts2 Gene Detail
Summary
  • Symbol
    Lzts2
  • Name
    leucine zipper, putative tumor suppressor 2
  • Synonyms
    MGC:7094, mKIAA1813
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385095
    NCBI Gene: 226154
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45003615-45015554 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385095
 protein coding gene Chr19:45002853-45015554 (+)
129S1/SvImJ ENSMUSG00200021345
 protein coding gene Chr19:41724905-41730646 (+)
A/J ENSMUSG00195014376
 protein coding gene Chr19:41860210-41865926 (+)
AKR/J ENSMUSG00220019086
 protein coding gene Chr19:41654640-41660374 (+)
BALB/cJ ENSMUSG00180017297
 protein coding gene Chr19:42112553-42118266 (+)
C3H/HeJ ENSMUSG00175006006
 protein coding gene Chr19:41641452-41647138 (+)
C57BL/6NJ ENSMUSG00215004313
 protein coding gene Chr19:41700856-41706604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023009
 protein coding gene Chr19:41680323-41692508 (+)
CAST/EiJ ENSTCUG00005014973
 protein coding gene Chr19:41297002-41302724 (+)
CBA/J ENSMUSG00210018272
 protein coding gene Chr19:41721021-41726705 (+)
DBA/2J ENSMUSG00185008485
 protein coding gene Chr19:42236173-42241890 (+)
FVB/NJ ENSMUSG00205020243
 protein coding gene Chr19:41148815-41154527 (+)
JF1/MsJ ENSUMUG00000040424
 protein coding gene Chr19:42377951-42383651 (+)
LP/J ENSMUSG00230022540
 protein coding gene Chr19:42994789-43000531 (+)
NOD/ShiLtJ ENSMUSG00190004565
 protein coding gene Chr19:41591983-41597712 (+)
NZO/HlLtJ ENSMUSG00225041900
 protein coding gene Chr19:46589130-46594867 (+)
PWK/PhJ ENSLUMG00010001051
 protein coding gene Chr19:41542501-41548212 (+)
SPRET/EiJ ENSMSPG00010006619
 protein coding gene Chr19:41283947-41292867 (+)
WSB/EiJ ENSIUOG00005006014
 protein coding gene Chr19:41095951-41101643 (+)



Homology
more
  • Human Ortholog
    LZTS2, leucine zipper tumor suppressor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LZTS2, leucine zipper tumor suppressor 2
  • Synonyms
    LAPSER1
  • Links
    NCBI Gene ID: 84445
    UniProt: Q9BRK4

  • Chr Location
    10q24.31; chr10:100996539-101007852 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lzts2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display defects in urinary tract development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    30
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226154 NCBI Gene Model | MGI Sequence Detail 11940 C57BL/6J ±  kb
    transcript NM_145503 RefSeq | MGI Sequence Detail 2825 C57BL/6  
    polypeptide Q91YU6 UniProt | EBI | MGI Sequence Detail 671 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Other 3
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory