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Sesn1 Gene Detail
Summary
  • Symbol
    Sesn1
  • Name
    sestrin 1
  • Synonyms
    1110002G11Rik, PA26, SEST1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155278
    NCBI Gene: 140742
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:41686570-41784432 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2033 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155278
 protein coding gene Chr10:41685931-41784432 (+)
129S1/SvImJ ENSMUSG00200008556
 protein coding gene Chr10:38649762-38670796 (+)
A/J ENSMUSG00195015263
 protein coding gene Chr10:38924973-38945957 (+)
AKR/J ENSMUSG00220026149
 protein coding gene Chr10:38601455-38622445 (+)
BALB/cJ ENSMUSG00180016206
 protein coding gene Chr10:39010053-39031046 (+)
C3H/HeJ ENSMUSG00175011144
 protein coding gene Chr10:38804326-38825310 (+)
C57BL/6NJ ENSMUSG00215007010
 protein coding gene Chr10:38553659-38574647 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015275
 protein coding gene Chr10:37250146-37328416 (+)
CAST/EiJ ENSTCUG00005027865
 protein coding gene Chr10:38999666-39020367 (+)
CBA/J ENSMUSG00210025300
 protein coding gene Chr10:38697790-38718773 (+)
DBA/2J ENSMUSG00185006526
 protein coding gene Chr10:38850437-38871423 (+)
FVB/NJ ENSMUSG00205011309
 protein coding gene Chr10:38765631-38786617 (+)
JF1/MsJ ENSUMUG00000027283
 protein coding gene Chr10:38635540-38656209 (+)
LP/J ENSMUSG00230005212
 protein coding gene Chr10:40639600-40660629 (+)
NOD/ShiLtJ ENSMUSG00190026488
 protein coding gene Chr10:38978598-38999581 (+)
NZO/HlLtJ ENSMUSG00225016571
 protein coding gene Chr10:44943424-44964415 (+)
PWK/PhJ ENSLUMG00010007497
 protein coding gene Chr10:38758692-38779552 (+)
SPRET/EiJ ENSMSPG00010019941
 protein coding gene Chr10:39787715-39808368 (+)
WSB/EiJ ENSIUOG00005015073
 protein coding gene Chr10:38528823-38549898 (+)



Homology
more
  • Human Ortholog
    SESN1, sestrin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SESN1, sestrin 1
  • Synonyms
    PA26, SEST1
  • Links
    NCBI Gene ID: 27244
    UniProt: Q9Y6P5

  • Chr Location
    6q21; chr6:108984309-109095074 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a kncok-out allele exhibit enhanced responsiveness to an influenza vaccine in aged mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    661
  • Tissues
    52
  • cDNA Data
    76
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140742 NCBI Gene Model | MGI Sequence Detail 97863 C57BL/6J ±  kb
    transcript NM_001162908 RefSeq | MGI Sequence Detail 3182 ZRU/MplStud  
    polypeptide P58006 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 76
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915788, MGI:2143767
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 24
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory