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Taf4 Gene Detail
Summary
  • Symbol
    Taf4
  • Name
    TATA-box binding protein associated factor 4
  • Synonyms
    Taf2c1, Taf4a, TAFII130, TAFII135
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152346
    NCBI Gene: 228980
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179553945-179618439 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 102.42 cM, cytoband H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1176 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152346
 protein coding gene Chr2:179553945-179618519 (-)
129S1/SvImJ ENSMUSG00200001514
 protein coding gene Chr2:175578669-175643386 (-)
A/J ENSMUSG00195001061
 protein coding gene Chr2:175815928-175880654 (-)
AKR/J ENSMUSG00220000087
 protein coding gene Chr2:173494527-173559246 (-)
BALB/cJ ENSMUSG00180000238
 protein coding gene Chr2:173618049-173682767 (-)
C3H/HeJ ENSMUSG00175004235
 protein coding gene Chr2:174777019-174841611 (-)
C57BL/6NJ ENSMUSG00215002557
 protein coding gene Chr2:173714657-173779171 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024769
 protein coding gene Chr2:169436812-169499467 (-)
CAST/EiJ ENSTCUG00005000498
 protein coding gene Chr2:173066402-173130962 (-)
CBA/J ENSMUSG00210000763
 protein coding gene Chr2:174096154-174160865 (-)
DBA/2J ENSMUSG00185019482
 protein coding gene Chr2:175336422-175401017 (-)
FVB/NJ ENSMUSG00205002275
 protein coding gene Chr2:174143783-174208506 (-)
JF1/MsJ ENSUMUG00000013577
 protein coding gene Chr2:176515761-176580527 (-)
LP/J ENSMUSG00230023443
 protein coding gene Chr2:177229657-177294370 (-)
NOD/ShiLtJ ENSMUSG00190016373
 protein coding gene Chr2:173637770-173702491 (-)
NZO/HlLtJ ENSMUSG00225006384
 protein coding gene Chr2:185317036-185381627 (-)
PWK/PhJ ENSLUMG00010000175
 protein coding gene Chr2:173940266-174005053 (-)
SPRET/EiJ ENSMSPG00010003809
 protein coding gene Chr2:176416729-176481515 (-)
WSB/EiJ ENSIUOG00005000191
 protein coding gene Chr2:173661701-173726291 (-)



Homology
more
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF4, TATA-box binding protein associated factor 4
  • Synonyms
    MRD73, TAF2C, TAF2C1, TAF4A, TAF(II)130, TAFII-130, TAFII130, TAF(II)135, TAFII-135, TAFII135
  • Links
    NCBI Gene ID: 6874
    UniProt: O00268

  • Chr Location
    20q13.33; chr20:61953469-62065881 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TAF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for deletions of this marker die embryonically sometime around E9.5. Conditional expression of this allele in the epidermis causes skin barrier defects and defects in hair growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    29
  • cDNA Data
    44
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039117 Ensembl Gene Model | MGI Sequence Detail 64495 C57BL/6J ±  kb
    transcript ENSMUST00000041618 Ensembl | MGI Sequence Detail 4416 Not Applicable  
    polypeptide ENSMUSP00000038610 Ensembl | MGI Sequence Detail 1042 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR009072 Histone-fold
      IPR003894 TAFH/NHR1
      IPR037249 TAFH/NHR1 domain superfamily
      IPR045144 Transcription initiation factor TFIID component TAF4
      IPR007900 Transcription initiation factor TFIID component TAF4, C-terminal
    • GlyGen
      E9QAP7 4 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 44
      Primer pair 3
      Other 1
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138960
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 10
      Gene Ontology 15
      Phenotypes 12
    • Earliest
      J:320038 Brand M, et al., Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem. 1999 Jun 25;274(26):18285-9
    • Latest
      J:333939 Saisa-Borreill S, et al., General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions. Cell Death Differ. 2023 Mar;30(3):839-853
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory