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Xrcc2 Gene Detail
Summary
  • Symbol
    Xrcc2
  • Name
    X-ray repair complementing 2
  • Synonyms
    4921524O04Rik, 8030409M04Rik, RecA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927345
    NCBI Gene: 57434
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:25894812-25910795 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 12.35 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    572 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927345
 protein coding gene Chr5:25894810-25910823 (-)
129S1/SvImJ ENSMUSG00200010182
 protein coding gene Chr5:21498475-21514440 (-)
A/J ENSMUSG00195043816
 protein coding gene Chr5:20961142-20977155 (-)
AKR/J ENSMUSG00220006984
 protein coding gene Chr5:21054667-21070680 (-)
BALB/cJ ENSMUSG00180031184
 protein coding gene Chr5:20840980-20856995 (-)
C3H/HeJ ENSMUSG00175046016
 protein coding gene Chr5:22769873-22785886 (-)
C57BL/6NJ ENSMUSG00215025276
 protein coding gene Chr5:21414516-21430529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027031
 protein coding gene Chr5:20589069-20605040 (-)
CAST/EiJ ENSTCUG00005023225
 protein coding gene Chr5:20969498-20985386 (-)
CBA/J ENSMUSG00210041042
 protein coding gene Chr5:21798571-21814584 (-)
DBA/2J ENSMUSG00185032694
 protein coding gene Chr5:23329475-23345528 (-)
FVB/NJ ENSMUSG00205026515
 protein coding gene Chr5:20613724-20629737 (-)
JF1/MsJ ENSUMUG00000005267
 protein coding gene Chr5:27898918-27914782 (-)
LP/J ENSMUSG00230023780
 protein coding gene Chr5:27780390-27796355 (-)
NOD/ShiLtJ ENSMUSG00190011965
 protein coding gene Chr5:20886450-20902479 (-)
NZO/HlLtJ ENSMUSG00225020076
 protein coding gene Chr5:33182829-33198882 (-)
PWK/PhJ ENSLUMG00010036749
 protein coding gene Chr5:20942883-20958725 (-)
SPRET/EiJ ENSMSPG00010042934
 protein coding gene Chr5:21813549-21828296 (-)
WSB/EiJ ENSIUOG00005036921
 protein coding gene Chr5:23696305-23712058 (-)



Homology
more
  • Human Ortholog
    XRCC2, X-ray repair cross complementing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XRCC2, X-ray repair cross complementing 2
  • Synonyms
    FANCU, POF17, SPGF50
  • Links
    NCBI Gene ID: 7516
    UniProt: O43543

  • Chr Location
    7q36.1; chr7:152644776-152676193 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human XRCC2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit chromosomal instability, excess neuronal apoptosis, and lethality ranging from midgestation through birth. Neonates die from respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    1
  • cDNA Data
    34
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57434 NCBI Gene Model | MGI Sequence Detail 15984 C57BL/6J ±  kb
    transcript NM_020570 RefSeq | MGI Sequence Detail 3230 Not Specified  
    polypeptide Q9CX47 UniProt | EBI | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918160, MGI:1925986
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 11
      Phenotypes 29
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory