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Tmprss6 Gene Detail
Summary
  • Symbol
    Tmprss6
  • Name
    transmembrane serine protease 6
  • Synonyms
    1300008A22Rik, matriptase-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919003
    NCBI Gene: 71753
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78323867-78352834 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.49 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    802 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919003
 protein coding gene Chr15:78323867-78352848 (-)
129S1/SvImJ ENSMUSG00200052138
 protein coding gene Chr15:75432675-75461636 (-)
A/J ENSMUSG00195046510
 protein coding gene Chr15:75374985-75403951 (-)
AKR/J ENSMUSG00220045151
 protein coding gene Chr15:75418445-75447411 (-)
BALB/cJ ENSMUSG00180045251
 protein coding gene Chr15:75252042-75281005 (-)
C3H/HeJ ENSMUSG00175050941
 protein coding gene Chr15:75563362-75592327 (-)
C57BL/6NJ ENSMUSG00215049800
 protein coding gene Chr15:75332770-75361736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019984
 protein coding gene Chr15:72436681-72466167 (-)
CAST/EiJ ENSTCUG00005037700
 protein coding gene Chr15:74879076-74907956 (-)
CBA/J ENSMUSG00210047368
 protein coding gene Chr15:75338564-75367527 (-)
DBA/2J ENSMUSG00185047120
 protein coding gene Chr15:75348359-75377329 (-)
FVB/NJ ENSMUSG00205035155
 protein coding gene Chr15:75068171-75097146 (-)
JF1/MsJ ENSUMUG00000020053
 protein coding gene Chr15:74927021-74956255 (-)
LP/J ENSMUSG00230050105
 protein coding gene Chr15:78681149-78710112 (-)
NOD/ShiLtJ ENSMUSG00190031095
 protein coding gene Chr15:75361370-75390312 (-)
NZO/HlLtJ ENSMUSG00225052894
 protein coding gene Chr15:79012358-79041327 (-)
PWK/PhJ ENSLUMG00010044823
 protein coding gene Chr15:75149528-75178820 (-)
SPRET/EiJ ENSMSPG00010049892
 protein coding gene Chr15:76810551-76839432 (-)
WSB/EiJ ENSIUOG00005045055
 protein coding gene Chr15:75414748-75443652 (-)



Homology
more
  • Human Ortholog
    TMPRSS6, transmembrane serine protease 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS6, transmembrane serine protease 6
  • Synonyms
    IRIDA, MT2
  • Links
    NCBI Gene ID: 164656
    UniProt: Q8IU80

  • Chr Location
    22q12.3; chr22:37065005-37110890 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TMPRSS6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 8 alleles in 11 genetic backgrounds
    33 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for an inactivating mutation of this gene results in hair loss over the entire body except the face, microcytic anemia and female infertility, all reversible by dietary iron supplementation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    638
  • Tissues
    33
  • cDNA Data
    69
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016942 Ensembl Gene Model | MGI Sequence Detail 28968 C57BL/6J ±  kb
    transcript ENSMUST00000017086 Ensembl | MGI Sequence Detail 3192 Not Applicable  
    polypeptide ENSMUSP00000017086 Ensembl | MGI Sequence Detail 811 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 69
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 74
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory