Pdss2 MGI Mouse Gene Detail - MGI:1918615 - prenyl (solanesyl) diphosphate synthase, subunit 2

Symbol

Pdss2
Name

prenyl (solanesyl) diphosphate synthase, subunit 2
Synonyms

5430420P03Rik, kd, mDLP1, PLMP

Feature Type

protein coding gene
IDs

MGI:1918615
NCBI Gene: 71365
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:43097482-43340878 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.91 cM, cytoband B2
Mapping Data

4 experiments

SNPs within 2kb

6049 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918615	protein coding gene	Chr10:43095396-43340878 (+)
129S1/SvImJ	ENSMUSG00200008810	protein coding gene	Chr10:39984056-40227205 (+)
A/J	ENSMUSG00195014994	protein coding gene	Chr10:40259933-40503390 (+)
AKR/J	ENSMUSG00220026608	protein coding gene	Chr10:39949127-40192558 (+)
BALB/cJ	ENSMUSG00180015901	protein coding gene	Chr10:40344054-40587471 (+)
C3H/HeJ	ENSMUSG00175011454	protein coding gene	Chr10:40139101-40382505 (+)
C57BL/6NJ	ENSMUSG00215009502	protein coding gene	Chr10:39888448-40131883 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015286	protein coding gene	Chr10:38641673-38879830 (+)
CAST/EiJ	ENSTCUG00005025779	protein coding gene	Chr10:40341188-40585164 (+)
CBA/J	ENSMUSG00210025333	protein coding gene	Chr10:40032619-40276019 (+)
DBA/2J	ENSMUSG00185007266	protein coding gene	Chr10:40185208-40428608 (+)
FVB/NJ	ENSMUSG00205012905	protein coding gene	Chr10:40100473-40343929 (+)
JF1/MsJ	ENSUMUG00000024362	protein coding gene	Chr10:39993255-40232154 (+)
LP/J	ENSMUSG00230005681	protein coding gene	Chr10:41973820-42216951 (+)
NOD/ShiLtJ	ENSMUSG00190024965	protein coding gene	Chr10:40313279-40556672 (+)
NZO/HlLtJ	ENSMUSG00225016844	protein coding gene	Chr10:46278120-46521540 (+)
PWK/PhJ	ENSLUMG00010007730	protein coding gene	Chr10:40089624-40325913 (+)
SPRET/EiJ	ENSMSPG00010012623	protein coding gene	Chr10:41127935-41378782 (+)
WSB/EiJ	ENSIUOG00005014266	protein coding gene	Chr10:39867574-40102342 (+)

Human Ortholog

PDSS2, decaprenyl diphosphate synthase subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDSS2, decaprenyl diphosphate synthase subunit 2
Synonyms

bA59I9.3, C6orf210, COQ10D3, COQ1B, DLP1, hDLP1
Links

HGNC:23041

NCBI Gene ID: 57107

UniProt: Q86YH6
Chr Location

6q21; chr6:107152556-107459580 (-) GRCh38

MGI Vertebrate Homology

Pdss2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDSS2
Gene Tree

Pdss2

Diseases

1 with Pdss2 mouse models; 1 with human PDSS2 associations

Human Disease

Mouse Models

coenzyme Q10 deficiency disease

IDs

View 1 model

primary coenzyme Q10 deficiency 3

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

79 phenotypes from 6 alleles in 6 genetic backgrounds
8 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Spontaneous

1
Targeted

8
Genomic Mutations

2 involving Pdss2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene result in renal abnormalities leading to early death.

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All GO Annotations

37
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

635
Tissues

23
cDNA Data

22
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdss2

ZFIN pdss2

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All Sequences

59
RefSeq

13
UniProt

3
CCDS

CCDS35891.1, CCDS48552.1

Ensembl

ENSMUSG00000038240 (Evidence)
NCBI Gene

71365

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038240	Ensembl Gene Model \| MGI Sequence Detail	243397	C57BL/6J	± kb
transcript	ENSMUST00000095725	Ensembl \| MGI Sequence Detail	2127	Not Applicable
polypeptide	ENSMUSP00000093393	Ensembl \| MGI Sequence Detail	401	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012522 all trans-polyprenyl-diphosphate synthase PDSS2

(term hierarchy)
EC

2.5.1.91
InterPro Domains

IPR008949 Isoprenoid synthase domain superfamily

IPR000092 Polyprenyl synthetase-like

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 4

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MGD-MRK-11583, MGI:96674

Summaries

All 74

Developmental Gene Expression 3

Diseases 1

Gene Ontology 16

Phenotypes 39
Earliest

J:5232 Lyon MF, et al., An inherited kidney disease of mice resembling human nephronophthisis. J Med Genet. 1971 Mar;8(1):41-8
Latest

J:375911 Rogg M, et al., Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease. Sci Adv. 2025 Nov 28;11(48):eady1623

TSS for Pdss2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93128	Chr10:43097462-43097497 (+)	-2 bp
Tssr93129	Chr10:43097501-43097525 (+)	31 bp
Tssr3188	Chr10:43314469-43314470 (+)	216,988 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24