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Icmt Gene Detail
Summary
  • Symbol
    Icmt
  • Name
    isoprenylcysteine carboxyl methyltransferase
  • Synonyms
    1700008E11Rik, Gm13095, HSTE14, pcCMT, prenylated protein carboxyl methyltransferase, prenylcysteine carboxyl methyltransferase, protein-S isoprenylcysteine O-methyltransferase, STE14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888594
    NCBI Gene: 57295
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152381684-152391578 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888594
 protein coding gene Chr4:152381671-152391583 (+)
129S1/SvImJ ENSMUSG00200018438
 protein coding gene Chr4:143448247-143458122 (+)
A/J ENSMUSG00195015995
 protein coding gene Chr4:145083950-145093844 (+)
AKR/J ENSMUSG00220025279
 protein coding gene Chr4:144670473-144680367 (+)
BALB/cJ ENSMUSG00180002304
 protein coding gene Chr4:142766140-142776034 (+)
C3H/HeJ ENSMUSG00175016661
 protein coding gene Chr4:146051028-146060922 (+)
C57BL/6NJ ENSMUSG00215017883
 protein coding gene Chr4:144894604-144904498 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026854
 protein coding gene Chr4:142196542-142206700 (+)
CAST/EiJ ENSTCUG00005028243
 protein coding gene Chr4:148769833-148779738 (+)
CBA/J ENSMUSG00210005580
 protein coding gene Chr4:144702677-144712571 (+)
DBA/2J ENSMUSG00185015300
 protein coding gene Chr4:148267598-148277492 (+)
FVB/NJ ENSMUSG00205018774
 protein coding gene Chr4:143164185-143174079 (+)
JF1/MsJ ENSUMUG00000005332
 protein coding gene Chr4:151295271-151305395 (+)
LP/J ENSMUSG00230017654
 protein coding gene Chr4:155000752-155010646 (+)
NOD/ShiLtJ ENSMUSG00190003320
 protein coding gene Chr4:144366831-144376725 (+)
NZO/HlLtJ ENSMUSG00225023025
 protein coding gene Chr4:158994197-159004091 (+)
PWK/PhJ ENSLUMG00010025070
 protein coding gene Chr4:143564398-143574531 (+)
SPRET/EiJ ENSMSPG00010023923
 protein coding gene Chr4:145499305-145506557 (+)
WSB/EiJ ENSIUOG00005006233
 protein coding gene Chr4:142576603-142586480 (+)



Homology
more
  • Human Ortholog
    ICMT, isoprenylcysteine carboxyl methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICMT, isoprenylcysteine carboxyl methyltransferase
  • Synonyms
    HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT
  • Links
    NCBI Gene ID: 23463
    UniProt: O60725

  • Chr Location
    1p36.31; chr1:6221193-6235972 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mutations result in reduced embryo size and death by E12. At E10.5, embryos homozygous for one null allele show severe anemia, extensive apoptosis in the neural tube and forebrain region, and liver agenesis due to a dramatic delay in albumin induction and failed hepatocyte outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    109
  • cDNA Data
    130
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039662 Ensembl Gene Model | MGI Sequence Detail 9895 C57BL/6J ±  kb
    transcript ENSMUST00000048892 Ensembl | MGI Sequence Detail 4919 Not Applicable  
    polypeptide ENSMUSP00000043390 Ensembl | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 135
      cDNA 131
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916534, MGI:2140687, MGI:3723264
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 23
    • Earliest
      J:60194 Lin X, et al., Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1 [see comments]. Nat Neurosci. 2000 Feb;3(2):157-63
    • Latest
      J:383245 Czarnota P, et al., ICMT deficiency ameliorates weight loss and mortality, but not tumor formation in a mouse model of liver cancer. Cell Commun Signal. 2026 Mar 11;24(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory