About   Help   FAQ
Clec7a Gene Detail
Summary
  • Symbol
    Clec7a
  • Name
    C-type lectin domain family 7, member a
  • Synonyms
    beta-glucan receptor, beta-GR, BGR, Clecsf12, dectin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861431
    NCBI Gene: 56644
  • Alliance
  • Transcription Start Sites
    42 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129438554-129449742 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.34 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861431
protein coding gene Chr6:129438554-129449748 (-)
129S1/SvImJ ENSMUSG00200043675
protein coding gene Chr6:126545130-126556316 (-)
A/J ENSMUSG00195028202
protein coding gene Chr6:125963228-125974414 (-)
AKR/J ENSMUSG00220036819
protein coding gene Chr6:124824828-124836010 (-)
BALB/cJ ENSMUSG00180033431
protein coding gene Chr6:126300144-126311322 (-)
C3H/HeJ ENSMUSG00175030558
protein coding gene Chr6:125980367-125991553 (-)
C57BL/6NJ ENSMUSG00215013351
protein coding gene Chr6:126268812-126279996 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008957
polymorphic pseudogene Chr6:126356647-126367998 (-)
CAST/EiJ ENSTCUG00005037964
protein coding gene Chr6:126306676-126317814 (-)
CBA/J ENSMUSG00210016548
protein coding gene Chr6:126000190-126011374 (-)
DBA/2J ENSMUSG00185036841
protein coding gene Chr6:126700952-126712136 (-)
FVB/NJ ENSMUSG00205035409
protein coding gene Chr6:125554688-125565876 (-)
JF1/MsJ ENSUMUG00000024913
protein coding gene Chr6:125317029-125328203 (-)
LP/J ENSMUSG00230038927
protein coding gene Chr6:127897584-127908766 (-)
NOD/ShiLtJ ENSMUSG00190026133
protein coding gene Chr6:125705880-125717058 (-)
NZO/HlLtJ ENSMUSG00225015199
protein coding gene Chr6:130184696-130196026 (-)
PWK/PhJ ENSLUMG00010040159
protein coding gene Chr6:124500523-124511744 (-)
SPRET/EiJ ENSMSPG00010032148
protein coding gene Chr6:127238607-127248350 (-)
WSB/EiJ ENSIUOG00005043920
protein coding gene Chr6:126423629-126434820 (-)



Homology
more
  • Human Ortholog
    CLEC7A, C-type lectin domain containing 7A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC7A, C-type lectin domain containing 7A
  • Synonyms
    BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
  • Links
    NCBI Gene ID: 64581
    UniProt: Q9BXN2

  • Chr Location
    12p13.2; chr12:10116777-10130304 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human CLEC7A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in increased susceptibility and defective inflammatory responses in response to fungal infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079293 Ensembl Gene Model | MGI Sequence Detail 11189 C57BL/6J ±  kb
    transcript ENSMUST00000195589 Ensembl | MGI Sequence Detail 2272 Not Applicable  
    polypeptide ENSMUSP00000141234 Ensembl | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 239
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 159
    • Earliest
      J:62992 Ariizumi K, et al., Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem. 2000 Jun 30;275(26):20157-67
    • Latest
      J:386522 King AE, et al., Loss of Fgr41 in Candida albicans attenuates virulence and increases proinflammatory immune responses in a manner that is dependent on beta(1,3)-glucan but not dectin-1. Infect Immun. 2026 Apr 15;94(4):e0052325

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory