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Arhgef7 Gene Detail
Summary
  • Symbol
    Arhgef7
  • Name
    Rho guanine nucleotide exchange factor
  • Synonyms
    betaPix, betaPix-b, betaPix-c, Cool, cool-1, p85SPR, Pak interacting exchange factor, PIX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860493
    NCBI Gene: 54126
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:11778053-11885219 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2629 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860493
 protein coding gene Chr8:11777721-11885219 (+)
129S1/SvImJ ENSMUSGG00200054557
 protein coding gene Chr8:8660214-8714562 (+)
129S1/SvImJ ENSMUSG00200010100
 protein coding gene Chr8:8714622-8767200 (+)
A/J ENSMUSG00195009628
 protein coding gene Chr8:9074312-9126903 (+)
A/J ENSMUSGG00195055167
 protein coding gene Chr8:9019902-9074252 (+)
AKR/J ENSMUSG00220010294
 protein coding gene Chr8:8803567-8856158 (+)
AKR/J ENSMUSGG00220054677
 protein coding gene Chr8:8749160-8803507 (+)
BALB/cJ ENSMUSGG00180054997
 protein coding gene Chr8:8658992-8713346 (+)
BALB/cJ ENSMUSG00180004492
 protein coding gene Chr8:8713406-8766004 (+)
C3H/HeJ ENSMUSGG00175054586
 protein coding gene Chr8:8818918-8873263 (+)
C3H/HeJ ENSMUSG00175008021
 protein coding gene Chr8:8873323-8925914 (+)
C57BL/6NJ ENSMUSG00215005270
 protein coding gene Chr8:8747659-8800249 (+)
C57BL/6NJ ENSMUSGG00215055506
 protein coding gene Chr8:8693252-8747599 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030821
 protein coding gene Chr8:8178899-8298793 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054765
 protein coding gene Chr8:8652789-8707131 (+)
CBA/J ENSMUSG00210010551
 protein coding gene Chr8:8707191-8759775 (+)
DBA/2J ENSMUSG00185003426
 protein coding gene Chr8:8839963-8892547 (+)
DBA/2J ENSMUSGG00185057767
 protein coding gene Chr8:8785556-8839903 (+)
FVB/NJ ENSMUSG00205004557
 protein coding gene Chr8:8732578-8785173 (+)
FVB/NJ ENSMUSGG00205054395
 protein coding gene Chr8:8678166-8732518 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055652
 protein coding gene Chr8:10967978-11022354 (+)
LP/J ENSMUSG00230018844
 protein coding gene Chr8:11022414-11075560 (+)
NOD/ShiLtJ ENSMUSGG00190054751
 protein coding gene Chr8:8777708-8832055 (+)
NOD/ShiLtJ ENSMUSG00190010260
 protein coding gene Chr8:8832115-8884702 (+)
NZO/HlLtJ ENSMUSGG00225055160
 protein coding gene Chr8:18820252-18874597 (+)
NZO/HlLtJ ENSMUSG00225017117
 protein coding gene Chr8:18874657-18927232 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010015301
 protein coding gene Chr8:8855564-8963500 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ARHGEF7, Rho guanine nucleotide exchange factor 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF7, Rho guanine nucleotide exchange factor 7
  • Synonyms
    BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
  • Links
    NCBI Gene ID: 8874
    UniProt: Q14155

  • Chr Location
    13q34; chr13:111114559-111305737 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit placental defects and complete lethality throughout fetal growth and development. Mice homozygous for a different null allele exhibit embryonic death around E8.5, double axis, and impaired anterior visceral endoderm cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    50
  • cDNA Data
    175
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54126 NCBI Gene Model | MGI Sequence Detail 107167 C57BL/6J ±  kb
    transcript NM_001113517 RefSeq | MGI Sequence Detail 4973 C57BL/6  
    polypeptide Q9ES28 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 178
      Genomic 1
      cDNA 176
      Primer pair 1
      Antibodies 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 11
      Gene Ontology 20
      Phenotypes 23
    • Earliest
      J:63104 Oh WK, et al., Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem Biophys Res Commun. 1997 Jun 27;235(3):794-8
    • Latest
      J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory