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Wdr45 Gene Detail
Summary
  • Symbol
    Wdr45
  • Name
    WD repeat domain 45
  • Synonyms
    C79260, DXImx38e, JM5, Sfc19, Wdrx1
Location &
Maps
more
  • Sequence Map
    ChrX:7588212-7594439 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.48 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859606
 protein coding gene ChrX:7580572-7594445 (+)
129S1/SvImJ ENSMUSG00200032361
 protein coding gene ChrX:2290711-2295140 (+)
A/J ENSMUSG00195037885
 protein coding gene ChrX:2313676-2318105 (+)
AKR/J ENSMUSG00220033515
 protein coding gene ChrX:2301705-2306130 (+)
BALB/cJ ENSMUSG00180026539
 protein coding gene ChrX:2290292-2294721 (+)
C3H/HeJ ENSMUSG00175032091
 protein coding gene ChrX:2325361-2329790 (+)
C57BL/6NJ ENSMUSG00215038290
 protein coding gene ChrX:2989198-2993627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032894
 protein coding gene ChrX:1865699-1871798 (+)
CAST/EiJ ENSTCUG00005033116
 protein coding gene ChrX:2261178-2265602 (+)
CBA/J ENSMUSG00210036249
 protein coding gene ChrX:2342234-2346663 (+)
DBA/2J ENSMUSG00185027619
 protein coding gene ChrX:8959367-8963796 (+)
FVB/NJ ENSMUSG00205019517
 protein coding gene ChrX:2335990-2340419 (+)
JF1/MsJ ENSUMUG00000027972
 protein coding gene ChrX:22845811-22850236 (+)
LP/J ENSMUSG00230028337
 protein coding gene ChrX:13479592-13484021 (+)
NOD/ShiLtJ ENSMUSG00190035970
 protein coding gene ChrX:2316574-2321006 (+)
NZO/HlLtJ ENSMUSG00225045620
 protein coding gene ChrX:18745098-18749527 (+)
PWK/PhJ ENSLUMG00010029031
 protein coding gene ChrX:2306207-2310635 (+)
SPRET/EiJ ENSMSPG00010023961
 protein coding gene ChrX:2341579-2347722 (+)
WSB/EiJ ENSIUOG00005029744
 protein coding gene ChrX:16206802-16211232 (-)



Homology
more
  • Human Ortholog
    WDR45, WD repeat domain 45
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR45, WD repeat domain 45
  • Synonyms
    JM5, NBIA4, NBIA5, WDRX1, WIPI-4, WIPI4
  • Links
    NCBI Gene ID: 11152
    UniProt: Q9Y484

  • Chr Location
    Xp11.23; chrX:49074433-49101203 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wdr45 mouse models; 1 with human WDR45 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons exhibit impaired autophagy, axonal swelling and degeneration and impaired learning and memory function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    66
  • cDNA Data
    61
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54636 NCBI Gene Model | MGI Sequence Detail 6228 C57BL/6J ±  kb
    transcript NR_189681 RefSeq | MGI Sequence Detail 2067 C57BL/6  
    polypeptide Q91VM3 UniProt | EBI | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 5
      cDNA 62
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2148058
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory